The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin

T Hoffmann, F Klemm, TI Kichko, SK Sauer… - Physiological …, 2022 - Wiley Online Library
… species difference cannot easily be explained by our recent work on the formalin test. …
In the experiments to determine the formaldehyde threshold concentration in the isolated rat

[HTML][HTML] Involvement of NO in antinociception of NSAIDS in murine formalin hind paw assay

V Noriega, HF Miranda, JC Prieto… - Drug …, 2020 - thieme-connect.com
… of the spinal cord after noxious stimulation. Besides, … Statistical difference between
before and after the treatment … both phases of the hind paw formalin test. It is know, that after …

[HTML][HTML] Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Exert Antinociceptive Activity in the Tail-Flick and Formalin Test in Rodents and Reveal …

M Szandruk-Bender, B Wiatrak, Ł Szczukowski… - International Journal of …, 2020 - mdpi.com
… and 13b, on antinociceptive behavior in noxious stimuli induced models of pain, ie, the
tail-flick test in rats and formalin test in mice, and compare this effect to the reference drugs such …

[HTML][HTML] Comparison of analgesic activities of aconitine in different mice pain models

J Deng, J Han, J Chen, Y Zhang, Q Huang, Y Wang… - PLoS …, 2021 - journals.plos.org
… Acetic acid is typically used as noxious stimuli in visceral pain … As a result, non-steroidal
anti-inflammatory agents (NSAIDs) … could significantly reduce formalin-induced paw licking time …

Analgesic effects of intravenous curcumin in the rat formalin test

HG Ok, HW Kim, HK Kim - Journal of Inclusion Phenomena and …, 2021 - Springer
… as a spice and food-coloring agent, is a major component of … of pain response caused by
noxious stimuli. As such, shows … statistically significant difference compared to control group (…

[HTML][HTML] … Antinociceptive Efficacy of Peel Extracts and Lyophilized Juices of Three Varieties of Mexican Pomegranate (Punica granatum L.) in the Formalin Test

JA Guerrero-Solano, M Bautista, JV Espinosa-Juárez… - Plants, 2022 - mdpi.com
… used as preventive and therapeutic agents since ancient times. … to the presence of potentially
noxious stimuli, which assume a … Therefore, this study aims to evaluate and compare the …

[HTML][HTML] Formalin itch test: low-dose formalin induces histamine-independent, TRPA1-mediated itch in mice

X Liu, JT Zhang, Y Hu, WQ Shan, ZH Wang… - Frontiers in …, 2021 - frontiersin.org
… remove potential harmfulformalin test in both mice and rats was widely used for pain
research, these results indicated that there are significant species differences for low-dose formalin

Anti-nociceptive and antioxidant activity of betaine on formalin-and writhing tests induced pain in mice

S Hassanpour, H Rezaei, SM Razavi - Behavioural brain research, 2020 - Elsevier
… Then the formalin test was done and paw licking time was … ; and mitigator of noxious elevated
homocysteine [9]. The latter … biting time of the injected paw compared to the control group …

[HTML][HTML] Overview of neurological mechanism of pain profile used for animal “pain-like” behavioral study with proposed analgesic pathways

MF Yam, YC Loh, CW Oo, R Basir - International journal of molecular …, 2020 - mdpi.com
… Thus, this review solely focused on the complete protocol that … experiences together with
noxious perceptual information … formalin test is sensitive to centrally acting analgesic agents […

[HTML][HTML] Central H2 histaminergic and alpha-2 adrenergic receptors involvement in crocetin-induced antinociception in orofacial formalin pain in rats

A Erfanparast, E Tamaddonfard… - Veterinary Research …, 2020 - ncbi.nlm.nih.gov
… the descending regulation of noxious stimuli such as rostral … post-hoc test was applied to
compare the differences among … in hind paw and orofacial formalin tests of pain and a rat model …