Structural characterization of RNA binding to RNA recognition motif (RRM) domains using data integration, 3D modeling and molecular dynamic simulation

H Dhondge - 2023 - theses.hal.science
areas of research including data organization, integration, modelling and simulating biological
systems, and prediction … for all the 20 standard amino acid residue types at each position …

A transient α-helix in the N-terminal RNA recognition motif of polypyrimidine tract binding protein senses RNA secondary structure

C Maris, S Jayne, FF Damberger, I Beusch… - Nucleic acids …, 2020 - academic.oup.com
… the α3 helix region, which is highly conserved in vertebrates, … N-terminal RRMs of PTB are
separated by a 42 amino acid … dissociation constants, which predict a negligible amount of …

Structural basis for mRNA recognition by human RBM38

K Qian, M Li, J Wang, M Zhang, M Wang - Biochemical Journal, 2020 - portlandpress.com
… has 239 amino acids, an N-terminal RRM and a C-terminal predicted flexible region, … in the
complex superimposed well with the previous apo RBM38 RRM nuclear magnetic resonance

Role of mutations in differential recognition of viral RNA molecules by peptides

A Kumar, H Vashisth - … of chemical information and modeling, 2022 - ACS Publications
… .2) peptide, by a highly conserved viral RNA element from the … (42) The proPka server
predicted the pK a values for Asp … similar regions in RRE RNA are involved in the recognition of …

PepCNN deep learning tool for predicting peptide binding residues in proteins using sequence, structural, and language model features

A Chandra, A Sharma, I Dehzangi, T Tsunoda… - Scientific reports, 2023 - nature.com
… sites allow the model to predict the binding sites in the same regions as the experimental …
amino acid in the ith position of the input sequence and has a high value for a highly conserved

Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition

S Roy, S Boral, S Maiti, T Kushwaha… - The FEBS …, 2022 - Wiley Online Library
… The remaining C-terminal residues were predicted to be … additional 26 amino acid residues
from the disordered region containing … The side chain amide resonances of Asn and Gln are …

Genome-wide identification of RNA recognition motif (RRM1) in Brassica rapa and functional analysis of RNA-binding protein (BrRBP) under low-temperature stress

L Ma, X Tao, W Wang, J Jiao, Y Pu, G Yang, L Liu… - BMC Plant …, 2023 - Springer
… ), is a region of approximately 80 to 90 amino acids containing many very conserved residues,
… The prediction and analysis of the protein amino acid length, theoretical isoelectric point, …

Structural basis for mRNA recognition by human Structural basis for mRNA recognition by human Structural basis for mRNA recognition by human RBM38.

K Qian, M Li, J Wang, M Zhang… - Biochemical …, 2020 - search.ebscohost.com
… has 239 amino acids, an N-terminal RRM and a C-terminal predicted flexible region, … well
with the previous apo RBM38RRM nuclear magnetic resonance (NMR) spectroscopy structure (…

Macromolecular Resonances

I Cosic, D Cosic - Rhythmic Oscillations in Proteins to Human Cognition, 2020 - Springer
… of our work on Resonant Recognition Model (RRM), which … protein biological function, predict
key amino acids (“hot spots”) … that such predicted amino acids denote residues crucial for …

Conserved molecular recognition by an intrinsically disordered region in the absence of sequence conservation

A Holehouse, J Alston, A Soranno - 2024 - researchsquare.com
… populated with relatively highly conserved residues. Disorder … residues 30-50) that is
predicted to interact directly with RNA. … the 30-50 amino acid region around the NTDSCO2and as …