Role of mammalian DNA methyltransferases in development

Z Chen, Y Zhang - Annual review of biochemistry, 2020 - annualreviews.org
DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian development.
DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the two DNMT …

The role of DNA methylation in genome-wide gene regulation during development

H Cedar, O Sabag, Y Reizel - Development, 2022 - journals.biologists.com
… it functions during the process of development remains unclear. Here, we propose that the
overall pattern of DNA methylation … Epigenetic reprogramming in mammalian development

[HTML][HTML] DNA methylation: a historical perspective

AL Mattei, N Bailly, A Meissner - Trends in Genetics, 2022 - cell.com
role and interpretation of DNA methylation patterns remain under investigation. Here, we
review the field of DNA methylation … an emphasis on findings in mammalian systems, and point …

[HTML][HTML] Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development

M Yagi, M Kabata, A Tanaka, T Ukai, S Ohta… - Nature …, 2020 - nature.com
… with DNMT3 mutations exhibit reduced DNA methylation at regions that are hypomethylated
DNA methylation target sites for both DNMT3 enzymes during mammalian development that …

DNA methylation networks underlying mammalian traits

A Haghani, CZ Li, TR Robeck, J Zhang, AT Lu… - Science, 2023 - science.org
DNA methylation profiles closely parallels that of genetics through evolution. Our results
demonstrate that DNA methylation … The publicly available data from our Mammalian Methylation

[HTML][HTML] Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

T Dahlet, A Argüeso Lleida, H Al Adhami… - Nature …, 2020 - nature.com
… detailed description of the multiple functions of DNA methylation in maintaining the transcription
… to our understanding of why DNA methylation is essential for mammalian development. …

[HTML][HTML] Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - Nature aging, 2023 - nature.com
Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

[HTML][HTML] RNA methylation in mammalian development and cancer

P Song, S Tayier, Z Cai, G Jia - Cell Biology and Toxicology, 2021 - Springer
… Overall, gene expression is tightly orchestrated with mammalian developmental processes
such as stem cell fate determination, embryonic development, and cancer susceptibility; and …

[HTML][HTML] Dynamics of DNA methylation and its functions in plant growth and development

S Kumar, T Mohapatra - Frontiers in Plant Science, 2021 - frontiersin.org
… The present review discusses the dynamics of DNA methylation (cytosine/adenine) in
plants, its functions in regulating gene expression under abiotic/biotic stresses, developmental

Role of genomic imprinting in mammalian development

T Thamban, V Agarwaal, S Khosla - Journal of biosciences, 2020 - Springer
DNA methylation has the ability to regulate transcription and … DNA methylation dynamics
during germ cell development ensures the erasure and re-establishment of DNA methylation in …