[HTML][HTML] How do adenosine A2A receptors regulate motor function?

A Mori - Parkinsonism & related disorders, 2020 - Elsevier
… NoGo signals via enhancement of GABAergic synaptic transmission to the GPe. … transmission,
is exerted by opposing presynaptic control of GABA release by A 2A receptors on striatal

[HTML][HTML] Adjusting the brakes to adjust neuronal activity: Adenosinergic modulation of GABAergic transmission

AM Sebastião, JA Ribeiro - Neuropharmacology, 2023 - Elsevier
… Our understanding on the ways adenosine uses to modulate synapses, circuits, and brain
… However, except for A 2A receptors, whose actions upon GABAergic neurons of the striatum

[HTML][HTML] Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum

S Ferré, LI Sarasola, C Quiroz, F Ciruela - Neuropharmacology, 2023 - Elsevier
… A 2A RD 2 R heteromers localized in the GABAergic striatal … Although the adenosine receptor
heteromers are proposed to … down-regulation of A 1 Rs in the cortex and striatum and up-…

Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson's Disease

FQ Gonçalves, FC Matheus, HB Silva, JI Real… - Molecular …, 2023 - Springer
… such as glutamate or GABA from synaptosomes reaches a near maximal … function to these
synaptic P2R in the control of glutamatergic synaptic transmission or plasticity in the striatum

[HTML][HTML] Pharmacological interactions between adenosine A2A receptor antagonists and different neurotransmitter systems

A Pinna, M Serra, J Marongiu, M Morelli - Parkinsonism & Related …, 2020 - Elsevier
… of the striatal indirect pathway [13]. In addition, a critical … in the regulation of synaptic
transmission and plasticity [46]. mGlu … during the release of GABA and glutamate from …

Adenosine receptors in neuropsychiatric disorders: fine regulators of neurotransmission and potential therapeutic targets

S Pasquini, C Contri, S Merighi, S Gessi… - International journal of …, 2022 - mdpi.com
… protein density and increased A 2A ARs in the striatum and … A 2A ARs influence BDNF
effects on GABAergic transmission, … AMPA receptor-mediated synaptic transmission [69]. …

Convergence of adenosine and GABA signaling for synapse stabilization during development

F Gomez-Castro, S Zappettini, JC Pressey, CG Silva… - Science, 2021 - science.org
… A 2A Rs act as detectors of active GABAergic synapses releasing GABA, adenosine triphosphate,
and adenosine to regulate … of synaptic transmission, the activation of either A 2A Rs or …

… together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA …

DO Borroto-Escuela, L Ferraro, S Beggiato… - Pharmacological …, 2021 - Springer
role of adenosine A2A receptor (A2AR) and striatal-enriched protein tyrosine phosphatase
(STEP) interactions in the striatal-pallidal GABAregulated by the dorsal striatal-pallidal GABA

[HTML][HTML] Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders

C Cervetto, G Maura, D Guidolin, S Amato, C Ceccoli… - …, 2023 - Elsevier
… , is given by adenosine A2A and dopamine D2 receptors on the … in synaptic transmission
and co-actors with neurons in the brain … regulate NMDA-mediated firing in striatopallidal GABA

Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures

K Nasrallah, C Berthoux, Y Hashimotodani, AE Chávez… - Cell Reports, 2024 - cell.com
… Here, we identified adenosine/A 2A receptor (A 2A R… synaptic inputs, a BDNF/TrkB-dependent
form of plasticity that facilitates seizures. Postsynaptic TrkB activation released adenosine