Impact of inflammatory cytokine and adipokine gene variations in the development of HIV‐associated lipodystrophy

G Namdev, R Choudhari, Shyamveer… - The Journal of Gene …, 2023 - Wiley Online Library
… They play a role in the development of lipodystrophy … and adipokine genes in patients of
HIV-associated lipodystrophy (… Hence, we studied the association of cytokine and adipokine

Adipocytokine dysregulation, abnormal glucose metabolism, and lipodystrophy in HIV-infected adolescents receiving protease inhibitors

J Santiprabhob, K Chokephaibulkit, P Khantee… - Cytokine, 2020 - Elsevier
lipodystrophy in perinatally HIV-infected adolescents receiving PI-based HAART. We also
evaluated the adipokine … different types of lipodystrophy and in patients without lipodystrophy. …

[HTML][HTML] Adipose tissue dysfunction and energy balance paradigms in people living with HIV

CER Bustamante, N Agarwal, AR Cox… - Endocrine …, 2024 - ncbi.nlm.nih.gov
… PLWH with excess visceral adipose tissue exhibit adipokine … PLWH with lipoatrophy compared
with people without HIV. In … from individuals with HIV-associated lipoatrophy demonstrate …

Synergic effect of metabolic syndrome and lipodystrophy on oxidative stress and inflammation process in treated HIV-patients

CM González-Domenech, IJ Plaza-Andrades… - … y Microbiología Clínica, 2022 - Elsevier
… In HIV-1 cohorts, metabolic and morphological changes are proved to be subordinate to
hormonal and adipokine … with lipoatrophy while higher leptin levels are linked to mixed forms of …

Approach to the patient with lipodystrophy

LT Fourman, SK Grinspoon - The Journal of Clinical …, 2022 - academic.oup.com
adipokine made by subcutaneous adipose tissue, metreleptin (recombinant human methionyl
leptin) is a pillar of therapy in non–HIV-associated lipodystrophy… in lipodystrophy, including …

[HTML][HTML] Altered pattern of circulating miRNAs in HIV lipodystrophy perturbs key adipose differentiation and inflammation pathways

S Srinivasa, R Garcia-Martin, M Torriani, KV Fitch… - JCI insight, 2021 - ncbi.nlm.nih.gov
… secreted in sEV and function as adipokines (13), could provide a novel mechanism for
altered adipose function and related metabolic abnormalities in HIV lipodystrophy. Interestingly, …

Metreleptin treatment of non-HIV lipodystrophy syndromes

B Chevalier, M Lemaitre, L Leguier, K Le Mapihan… - La Presse Médicale, 2021 - Elsevier
Lipodystrophy syndromes (LS) constitute a group of rare diseases of the adipose tissue, …
Because of a common pathophysiology involving decreased concentration of the adipokine

[HTML][HTML] Genetic and cytometric analyses of subcutaneous adipose tissue in patients with hemophilia and HIV-associated lipodystrophy

T Mashiko, K Tsukada, H Takada, SH Wu… - AIDS Research and …, 2022 - Springer
… , altered adipokine secretion and … function in fat from HIV patients, including inhibited
expression of POLG1 which was suggested as one of key factors in NRTI-induced lipoatrophy [8]. …

Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy

P Domingo, M Giralt, A Gavaldà-Navarro… - Adipocyte, 2022 - Taylor & Francis
HIV-associated lipodystrophy may be related to accelerated ageing elicited by antiretroviral
drugs and HIV … component in HIV lipodystrophy, we herein compared alterations in …

[HTML][HTML] HIV and antiretroviral therapy-related fat alterations

JR Koethe, C Lagathu, JE Lake, P Domingo… - Nature reviews Disease …, 2020 - nature.com
role in glucose and lipid metabolism and respond differentially to physiological cues or
metabolic stresses by releasing adipokines … with lipoatrophy include HIV-related factors, such as …