Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

MN Trinh, MS Brown, JL Goldstein… - Proceedings of the …, 2020 - National Acad Sciences
… This demonstrates that transmembrane movement of one lipid (cholesterol) requires … the
cholesterol content of another organelle (plasma membrane), thereby maintaining membrane

Cholesterol interaction with the trimeric HIV fusion protein gp41 in lipid bilayers investigated by solid-state NMR spectroscopy and molecular dynamics simulations

B Kwon, T Mandal, MR Elkins, Y Oh, Q Cui… - Journal of molecular …, 2020 - Elsevier
… a membrane-proximal external region (MPER) N-terminal to the TMD also exerts a significant
influence on membrane fusioncholesterol is important for gp41-mediated virus–cell fusion […

How cholesterol stiffens unsaturated lipid membranes

S Chakraborty, M Doktorova… - Proceedings of the …, 2020 - National Acad Sciences
… to our understanding of cholesterol-mediated biological functions. Here, using a … cholesterol
locally increases the bending rigidity of DOPC membranes, similar to saturated membranes, …

[HTML][HTML] Cholesterol-rich lipid rafts as platforms for SARS-CoV-2 entry

SN Palacios-Rápalo, LA De Jesus-Gonzalez… - Frontiers in …, 2021 - frontiersin.org
… the S protein catalyzed membrane fusion via blockade of cholesterol export in the late
endosomes (85). 25-HC is the product of cholesterol oxidation by the enzyme cholesterol-25-…

Staying in touch with the endocytic network: The importance of contacts for cholesterol transport

A Martello, FM Platt, ER Eden - Traffic, 2020 - Wiley Online Library
membranes, but without membrane fusion. These tethers can often be discerned by electron
microscopy, as multiple strands between the opposing membranes of the two organelles.8 …

[HTML][HTML] A role of cholesterol in modulating the binding of α-synuclein to synaptic-like vesicles

WK Man, A De Simone, JD Barritt… - Frontiers in …, 2020 - frontiersin.org
… the tendency to promote vesicle fusion. Each measurement was made of 10 replicates.
Error bars report standard deviations of the centers of the size distributions in the 10 replicates. …

[HTML][HTML] Pathways and mechanisms of cellular cholesterol efflux—insight from imaging

AD Juhl, D Wüstner - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
… cycle in membranes containing cholesterol compared to cholesterol-free membranes can be
… In addition, cholesterol can specifically interact with membrane proteins, thereby regulating …

[HTML][HTML] The role of high cholesterol in age-related COVID19 lethality.

H Wang, Z Yuan, MA Pavel, SM Jablonski, J Jablonski… - BioRxiv, 2020 - ncbi.nlm.nih.gov
… Here we show loading cells with cholesterol from blood serum using the cholesterol transport
protein apolipoprotein E (apoE) enhances the entry of pseudotyped SARS-CoV-2 and the …

Cholesterol, lipoproteins, and COVID-19: Basic concepts and clinical applications

E Kočar, T Režen, D Rozman - … et Biophysica Acta (BBA)-Molecular and …, 2021 - Elsevier
Membrane composition plays a crucial role in the behaviour of fusion proteins and also
influences membrane fusion … and dynamics of both included membranes [44]. However, the data …

[HTML][HTML] Role of cholesterol and lipid rafts in cancer signaling: a promising therapeutic opportunity?

R Vona, E Iessi, P Matarrese - Frontiers in cell and developmental …, 2021 - frontiersin.org
… of cholesterol homeostasis could lead to cancer development. This review aims to discuss the
current understanding of cholesterol … the role of major players in cholesterol regulation and …