… We provide evidence that amotosalen is an … IMPORTANCE Pathogen inactivation is a
strategy to enhance the safety of transfused blood products. We identify the compound, amotosalen…

… Amotosalen/UV- A cannot be used to effectively pathogen … irradiation for the prevention of
transfusion- associated graft- versus… safety of platelets treated with a photochemical process for …

… levels were found to be in the permissible range after photochemical inactivation. … and UVA
inactivation could be a masterstroke in preventing TTIs as it inactivates a broad spectrum of …

… T cells and preventing transfusion‐associated GVHD [33] … pathogen inactivation using the
amotosalen UV‐A method, but … Platelets photochemically treated with amotosalen HCI and …

… , amotosalen, and UV-A light to prevent nucleic acid replication, thereby inactivating infectious
agents and lymphocytes. Following INTERCEPT treatment, … a photochemical reaction that …

… photo or photochemical techniques: the amotosalen-UVA … the transfusion efficacy of
amotosalen-UVA treated platelets … with wavelengths in the range of 315 to 400 nm (UV-A), with …

… UV-A radiation) therapy, which inter alia can be used to treat … of action, the synthetic psoralen
amotosalen (AMO) is utilized … spectroscopy, intercalation and photochemistry of AMO and …

… In addition to improving blood safety by preventing the … UVA and UVB light–treated PLTs for
transfusion support in adults (… photochemically treated with amotosalen HCl and ultraviolet A …

… leukocytes for the prevention of transfusion-associated graft-… photodynamic process with
Riboflavin and UV A/B, damaging … uses a photochemical reaction with amotosalen, irreversibly …

… annually, making blood transfusion one of the most … (UV A) light ranging from 320 to 400
nm. To minimize the potentially toxic effects, we have a process to remove residual Amotosalen …