Leukemia inhibitory factor: Recent advances and implications in biotechnology
… leukemia inhibitory factor (LIF)), all of which that interact with the membrane glycoprotein 130
(gp130) as part of their signaling … found to display neuroprotective functions and emerged …
(gp130) as part of their signaling … found to display neuroprotective functions and emerged …
Leukemia inhibitory factor, a double-edged sword with therapeutic implications in human diseases
… -suppressive function in leukemia, recent studies have highlighted the oncogenic role of LIF
in … In this review, we summarize the recent insights into the roles and mechanisms of LIF in …
in … In this review, we summarize the recent insights into the roles and mechanisms of LIF in …
Neuroregenerative and protective functions of Leukemia Inhibitory Factor in perinatal hypoxic-ischemic brain injury
J Lin, Y Niimi, MG Clausi, HD Kanal, SW Levison - Experimental neurology, 2020 - Elsevier
… sensorimotor function in the P9 H single bond I mouse model of late preterm brain injury.
The neuroprotective effects exerted by LIF are likely due to multiple downstream signals. To …
The neuroprotective effects exerted by LIF are likely due to multiple downstream signals. To …
The emerging role of leukemia inhibitory factor in cancer and therapy
… a neuroprotective effect in a rat model of stroke through inducing the expression of transcription
factor … /S6K signaling pathway in nasopharyngeal carcinoma to enhance radioresistance, …
factor … /S6K signaling pathway in nasopharyngeal carcinoma to enhance radioresistance, …
[HTML][HTML] Leukemia inhibitory factor: an important cytokine in pathologies and cancer
MM Jorgensen, P de la Puente - Biomolecules, 2022 - mdpi.com
… is necessary to better understand the entirety of LIF signaling for the creation of effective LIF-…
of LIF in neovascularization of myocardium after the infarct [162], as well as neuroprotective …
of LIF in neovascularization of myocardium after the infarct [162], as well as neuroprotective …
[HTML][HTML] Norrin protects retinal ganglion cells from excitotoxic damage via the induction of leukemia inhibitory factor
S Kassumeh, S Leopold, R Fuchshofer, CN Thomas… - Cells, 2020 - mdpi.com
… and to an induction of neuroprotective factor [19]. In line with this signaling network, we detected
an … a central role of Lif for downstream signaling of the neuroprotective effects of Norrin. …
an … a central role of Lif for downstream signaling of the neuroprotective effects of Norrin. …
[HTML][HTML] Leukemia inhibitory factor protects photoreceptor cone cells against oxidative damage through activating JAK/STAT3 signaling
S Dong, F Zhen, H Xu, Q Li, J Wang - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
… Among these signaling events, JAK/STAT3 pathway had been considered to be the most …
genes important for neuroprotection. In the early 1990s, the neuroprotective effect of LIF was …
genes important for neuroprotection. In the early 1990s, the neuroprotective effect of LIF was …
[HTML][HTML] Leukemia inhibitory factor regulates Schwann cell proliferation and migration and affects peripheral nerve regeneration
Q Chen, Q Liu, Y Zhang, S Li, S Yi - Cell Death & Disease, 2021 - nature.com
… Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that stimulates neuronal development
and survival. Our previous study has demonstrated that LIF mRNA is dysregulated in the …
and survival. Our previous study has demonstrated that LIF mRNA is dysregulated in the …
The NF-κB/leukemia inhibitory factor/STAT3 signaling pathway in antibody-mediated suppression of Sindbis virus replication in neurons
JX Yeh, KLW Schultz, V Calvert… - Proceedings of the …, 2020 - National Acad Sciences
… The best-studied downstream effects of neuroprotective LIF signaling are up-regulation of
STAT3-induced proproliferation/survival genes, for example, c-fos, HIF-1a, survivin, and cyclin …
STAT3-induced proproliferation/survival genes, for example, c-fos, HIF-1a, survivin, and cyclin …
[HTML][HTML] Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer's disease
HM Mansour, HM Fawzy, AS El-Khatib… - Neural regeneration …, 2022 - journals.lww.com
… under-examined epidermal growth factor receptor downstream signaling pathways that
warrant more exploration. We conclude that epidermal growth factor receptor inhibitors are novel …
warrant more exploration. We conclude that epidermal growth factor receptor inhibitors are novel …