… The role of the time-kill kinetics assay as part of a preclinical modeling framework for
assessing the activity of anti-tuberculosis drugs. Tuberculosis. 2017;105:80–85. …

… new drug evaluation criteria to allow the assessment of … , any adaptation of MIC or time-kill
assay that ensures that the … for evaluating the activity of a drug in preclinical assays that are …

… in toxicology studies during preclinical development. However, it … in whole-cell assays to
evaluate their activity against the … tuberculosis, or in time-kill curves to have their mechanism of …

… Despite this importance, methods for determining numbers of … E max models applied to
time-kill data from FCM defined cell … study of mycobacteria in preclinical drug development and …

… the preclinical environment as a complementary tool to existing anti-tuberculosis research …
With time-kill experiments, the growth and killing kinetics of a pathogen are followed over time …

… preclinical tool to explore the effectiveness of various drug … The in vitro activity against a
pathogen over time is most … A robust system to evaluate the efficacy of antibiotic combinations in …

… patients, determining optimal dosing of antimicrobial agents for … over time (time-kill curves)
offer a more robust approach. … The mechanism controlling the activity of antimicrobial agents …

… laboratory testing strategies for assessing phage activity … and time-kill analyses have
been used to assess potential … mathematical modeling of preclinical infection model data (164…

… (PK/PD) of anti-tuberculosis drugs, various mathematical and … determining the MIC using
various methods, time-kill kinetic … modeling approach can bridge the translation of pre-clinical …

… Figure 3.21 Time-kill curves of meropenem/linezolid 4/32 μg/… Antibacterial Agents in
Clinical and Preclinical Development … It can be used to evaluate and prioritize potential drug …