Prostate epithelial RON signaling promotes M2 macrophage activation to drive prostate tumor growth and progression

C Sullivan, NE Brown, J Vasiliauskas, P Pathrose… - Molecular Cancer …, 2020 - AACR
… of the RON receptor tyrosine kinase as a major regulator of … of M1 macrophages may be
protective against prostate … Our in vitro experiments do not fully recapitulate the heterogeneous

MSP-RON pathway: potential regulator of inflammation and innate immunity

L Huang, X Fang, D Shi, S Yao, W Wu, Q Fang… - Frontiers in …, 2020 - frontiersin.org
… -RON in the development of drugs for autoimmune diseases. Moreover, MSP-RON plays an
… Here, we summarize the role of MSP-RON in immunity, based on recent findings, and lay …

Epithelial and macrophage RON receptor signaling regulates the antitumor immune response in prostate cancer

C Sullivan - 2020 - search.proquest.com
… demonstrates that the RON receptor tyrosine kinase, an … of M1 macrophages may be
protective against prostate … do not fully recapitulate the heterogeneous network of cell types …

Macrophage plasticity and atherosclerosis therapy

P Lin, HH Ji, YJ Li, SD Guo - Frontiers in molecular biosciences, 2021 - frontiersin.org
… , M2 macrophages in atherosclerosis are not always protective. … However, the concept of
macrophage heterogeneity within the … However, the Ron receptor tyrosine kinase expressed on …

Regulation of energy metabolism by receptor tyrosine kinase ligands

M Zhao, Y Jung, Z Jiang, KJ Svensson - Frontiers in physiology, 2020 - frontiersin.org
… The action of insulin as a receptor tyrosine kinase ligand will therefore not be directly
covered in this review, but it exemplifies the powerful actions that a single ligand-receptor

Research trends in pharmacological modulation of tumor‐associated macrophages

N Wang, S Wang, X Wang, Y Zheng… - Clinical and …, 2021 - Wiley Online Library
… Cancer is a heterogeneous disease that is composed of … via the MAPK/ ERK signaling
pathway; protecting cancer cells from … Tyrosine kinase receptors including CSF-1R and RON were …

MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system

JM Huelse, DM Fridlyand, S Earp, D DeRyckere… - Pharmacology & …, 2020 - Elsevier
… The receptor tyrosine kinase MERTK is aberrantly expressed in numerous human
malignancies, and is a novel target in cancer therapeutics. Physiologic roles of MERTK include …

Targeting RON receptor tyrosine kinase for treatment of advanced solid cancers: antibody–drug conjugates as lead drug candidates for clinical trials

HP Yao, SR Suthe, XM Tong… - Therapeutic advances in …, 2020 - journals.sagepub.com
… d’origine nantais (RON) in tumorigenesis has been … As a receptor tyrosine kinase belonging
to the mesenchymal-to-epithelial transition (MET) receptor proto-oncogene family, 3–5 RON

[HTML][HTML] Galectins as modulators of receptor tyrosine kinases signaling in health and disease

N Porębska, M Poźniak, A Matynia, D Żukowska… - Cytokine & Growth …, 2021 - Elsevier
Receptor tyrosine kinases (RTKs) constitute a large group of … regulated by numerous
mechanisms, including receptor … of co-receptors, cellular trafficking of the receptors or their post-…

Metabolic Profiling Reveals Aggravated Non-Alcoholic Steatohepatitis in High-Fat High-Cholesterol Diet-Fed Apolipoprotein E-Deficient Mice Lacking Ron Receptor …

JN Allen, A Dey, J Cai, J Zhang, Y Tian, M Kennett… - Metabolites, 2020 - mdpi.com
… -dependent Ron receptor activation provides protection from the … ) modulates macrophage
heterogeneity in many highly … KO) mice and Ron receptor tyrosine kinase deficient ApoE KO …