… binding of TSST-1 to the V beta domain of the T cell receptor (TCR) on T cells and the α-chain
of major histocompatibility complex class II (MHC-II) … , superantigenic activity, and lethality. …

… The present study proposes a new approach to produce a superantigen-positive lethality-negative
molecule for cancer immunotherapy. We synthesized SPEA superantigen-based …

… in the context of major histocompatibility complex (MHC) … domain of the TCR is comprised
of TCRα and TCRβ domains… off into the Virkon solution container and 50𝜇L of 2% PFA was …

… TCR β-domains by exploiting conserved MHC class II structures … organ failure that is specific
to each superantigen [79]. … with the major histocompatibility complex (MHC) class II [174]. If …

… amino acid substitutions in the Fc region at L234 and L235 … on the chip and receptor in
solution. The results are shown in … to bind to major histocompatibility complex (MHC) Class II …

… This thesis aimed to develop and evaluate a novel PolyStaphylococcal Superantigen-Like
(SSL) fusion vaccine to investigate SSLs as potential vaccine targets and the efficacy of a Poly…

… major histocompatibility complexes … (TSS) against superantigens, cytokine storm, and
the five classes of … The mTOR protein has an FKBP12-rapamycin binding domain, through …

… map the binding site for Epx2 to a1-a2 domains of MHC-I, which … from the structures of Epx1
and Epx4 we obtained in solution in … the pore structure in lipid membranes will be important. …

… of the adoptive immunity by binding to both Fc region of IgG and … superantigens bind only
to the T cell receptor (TCR) on the T-cells and major histocompatibility complex (MHC) class II …

… -binding domains capable of binding both … superantigens (eg, TSST-1, enterotoxins) that
non-specifically activate T cells by cross-linking the major histocompatibility complex of class II …