The therapeutic potential of soluble activin type IIB receptor treatment in a limb girdle muscular dystrophy type 2D mouse model
A Alqallaf, S Engelbeen, A Palo, F Cutrupi… - Neuromuscular …, 2022 - Elsevier
Limb girdle muscular dystrophy type 2D (LGMD2D) is characterized by progressive
weakening of muscles in the hip and shoulder girdles. It is caused by a mutation in the α-
sarcoglycan gene and results in absence of α-sarcoglycan in the dystrophin-glycoprotein
complex. The activin type IIB receptor is involved in the activin/myostatin pathway, with
myostatin being a negative regulator of muscle growth. In this study, we investigated the
effects of sequestering myostatin by a soluble activin type IIB receptor (sActRIIB) on muscle …
weakening of muscles in the hip and shoulder girdles. It is caused by a mutation in the α-
sarcoglycan gene and results in absence of α-sarcoglycan in the dystrophin-glycoprotein
complex. The activin type IIB receptor is involved in the activin/myostatin pathway, with
myostatin being a negative regulator of muscle growth. In this study, we investigated the
effects of sequestering myostatin by a soluble activin type IIB receptor (sActRIIB) on muscle …
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