… classes, including the ubiquitin-specific protease (USP) with … pathway signaling and a decrease
in growth factor-mediated … activated p53 consequences on ERK signaling pathway [126]. …

… of inhibitory ubiquitin chains that compete with ubiquitinated … families: ubiquitin-specific
proteases (USPs), ubiquitin C-… in these processes have many clinical implications. Examples of …

… Here, we comprehensively review the mechanisms, physiologic importance, and
pharmacological potential of UPS-mediated protein degradation in the control of MAPK signaling. …

… As aforementioned, USPs are a class of cysteine-dependent proteases, an analogous
mechanism of action of the cysteine protease papain. The catalytic domain (or USP domain) is the …

… enzymatic mechanism of ubiquitination occurs in a proteolytic and non-proteolytic pathway
… Increasing evidence demonstrates the implication of ubiquitin enzymes in carcinogenesis. …

… ligases are a large family of enzymes that promote ubiquitin transfer to proteins or
polyubiquitin chains [21]. E3 ligases play an important role in the ubiquitin-mediated proteolytic …

… mechanisms or through non-degradative mechanisms. Non-proteolytic roles of ubiquitin …
Although the myriad complexities of these linkages and their consequence are only starting …

… The ubiquitin proteasome system (UPS) is a proteolytic machinery for the degradation of …
-ubiquitin ligase-mediated protein turnover in immune cells via UPS has functional implications …

… In addition, the mechanism of action of the immunoproteasome inhibitors, ONX-0914 and
LU-102, … In the current review, we discuss various PIs and their underlying mechanisms in …

… The other proteolytic pathway involves ubiquitin, a polypeptide of 76 amino acids, which
acts as a marker for degradation, and a multienzymatic complex, the proteasome. The …