Type IV secretion systems: advances in structure, function, and activation

TRD Costa, L Harb, P Khara, L Zeng, B Hu… - Molecular …, 2021 - Wiley Online Library
… Upon binding of DNA or protein secretion substrates, how … poorly understood aspects of
type IV secretion. According to … of secretions associated with types II and III secretion systems, …

Mechanisms of secretion and spreading of pathological tau protein

CA Brunello, M Merezhko, RL Uronen… - Cellular and Molecular …, 2020 - Springer
… that aim to reduce the cellular burden of aggregated proteins and also promote secretion of
tau … mechanisms involved in cell-to-cell transfer of tau, with a particular focus in tau secretion. …

Mechanisms controlling pancreatic islet cell function in insulin secretion

JE Campbell, CB Newgard - Nature reviews Molecular cell biology, 2021 - nature.com
underlying mechanisms, particularly relating to the second or amplifying phase of this secretory
… a new perspective for the understanding of the β-cell failure that triggers type 2 diabetes. …

Contact-dependent interbacterial antagonism mediated by protein secretion machines

TA Klein, S Ahmad, JC Whitney - Trends in microbiology, 2020 - cell.com
… or (ii) antibacterial protein toxins that rely on protein secretion apparatuses to facilitate their
contact-dependent delivery to target cells. Examples of contact-independent antibacterial …

Envelope stress responses defend against type six secretion system attacks independently of immunity proteins

SJ Hersch, N Watanabe, MS Stietz, K Manera… - Nature …, 2020 - nature.com
… Although the exact underlying mechanisms for this protection require further investigation,
they might involve a healthy envelope providing a buffer of time to repair effector-mediated …

Exercise and type 2 diabetes

S Amanat, S Ghahri, A Dianatinasab… - Physical Exercise for …, 2020 - Springer
underlying mechanisms is regulation of inflammatory cytokines production. Exercise may
directly reduce the inflammatory cytokines secretion… decrease urine protein excretion likely due …

Type 2 immunity in the skin and lungs

CA Akdis, PD Arkwright, MC Brüggen, W Busse… - Allergy, 2020 - Wiley Online Library
… Th2 cells and innate lymphoid cells (ILC) produce and secrete type 2 cytokines such as IL-4…
type 2 immune components. The present review aims to highlight recent advances in type 2

Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria

I Alav, J Kobylka, MS Kuth, KM Pos, M Picard… - Chemical …, 2021 - ACS Publications
… marcescens employs the T1SS HasDEF/TolC to secrete the heme-binding protein HasA, …
reported to be involved in the secretion of enterotoxin II from the periplasm into the extracellular …

Emerging targets in type 2 diabetes and diabetic complications

S Demir, PP Nawroth, S Herzig… - Advanced …, 2021 - Wiley Online Library
… Senescence-associated secretory phenotype (SASP) which is shared in both type 2 diabetes
and … The exact underlying mechanisms that lead to metabolic memory remain elusive. …

Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations

C Ke, KMV Narayan, JCN Chan, P Jha… - Nature Reviews …, 2022 - nature.com
… Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. … an
underlying predisposition to deficient insulin secretion, which has a key role in the pathogenesis