High-throughput screening in multicellular spheroids for target discovery in the tumor microenvironment
B Calpe, WJ Kovacs - Expert opinion on drug discovery, 2020 - Taylor & Francis
… Since this spatial organization cannot be captured in 2D cell culture, high-throughput …
multicellular tumor spheroid (MTS) models are needed. This review will describe the current use of …
multicellular tumor spheroid (MTS) models are needed. This review will describe the current use of …
[HTML][HTML] Recent advances in three-dimensional multicellular spheroid culture and future development
H Shen, S Cai, C Wu, W Yang, H Yu, L Liu - Micromachines, 2021 - mdpi.com
… model for tumor research, high-throughput drug screening, … culture can achieve high-throughput
preparation of spheroids… and is suitable for high-throughput screening. Owing to their …
preparation of spheroids… and is suitable for high-throughput screening. Owing to their …
A framework for optimizing high-content imaging of 3D models for drug discovery
J Wardwell-Swanson, M Suzuki… - … the Science of Drug …, 2020 - journals.sagepub.com
… , multicellular spheroid models with scalable, automation-compatible plate technology enabling
image-based applications ranging from high-throughput screening … co-culture model of …
image-based applications ranging from high-throughput screening … co-culture model of …
3D multicellular tumor spheroids used for in vitro preclinical therapeutic screening
SM Roy, P Kishore, D Saha, P Ghosh, R Kar… - Journal of Drug Delivery …, 2023 - Elsevier
… Multicellular tumor spheroids are 3-dimensional, biomimetic and in vitro models of solid
tumors cultured under laboratory condition. It is used as a model for high throughput screening …
tumors cultured under laboratory condition. It is used as a model for high throughput screening …
[PDF][PDF] A 3D bioprinter specifically designed for the high-throughput production of matrix-embedded multicellular spheroids
… cell cultures in an efficient and high-throughput (HTP) … the spheroids (Figure 3D) compared
with free floating spheroids. … SK-N-BE(2) spheroids for high-throughput screening (HTS) was …
with free floating spheroids. … SK-N-BE(2) spheroids for high-throughput screening (HTS) was …
[HTML][HTML] 3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs
… compatibility with high-throughput screenings and automated … of culture methods and sphere
biology: multicellular tumor … to perform a high throughput screening on MCF-7 spheroids. …
biology: multicellular tumor … to perform a high throughput screening on MCF-7 spheroids. …
3D tumor spheroid models for in vitro therapeutic screening of nanoparticles
S Daunys, A Janonienė, I Januškevičienė… - Bio-Nanomedicine for …, 2021 - Springer
… attention is paid to high-throughput screening strategies, and … and pancreatic cancers) cultured
as 3D spheroid models has been … spheroid model could be multicellular tumor spheroids (…
as 3D spheroid models has been … spheroid model could be multicellular tumor spheroids (…
Two-dimensional and three-dimensional cartilage model platforms for drug evaluation and high-throughput screening assays
… the loss of the multicellular aggregates that subsequently … In summary, spheroids are a
sound 3D model for cartilage … large-scale spheroid culture 78 and high-throughput hydrogel …
sound 3D model for cartilage … large-scale spheroid culture 78 and high-throughput hydrogel …
[HTML][HTML] Optimization of 3D-aggregated spheroid model (3D-ASM) for selecting high efficacy drugs
SY Lee, HJ Hwang, DW Lee - Scientific Reports, 2022 - nature.com
… study of drug response with conventional 2D-high throughput screening (HTS), the 3D-HTS …
tumor-mimicking models. This paper describes a detailed spheroid culture protocol and …
tumor-mimicking models. This paper describes a detailed spheroid culture protocol and …
[HTML][HTML] Enabling high throughput drug discovery in 3D cell cultures through a novel bioprinting workflow
… high throughput screening assay AlphaLISA, we demonstrate the utility of the protocol in 3D
synthetic hydrogel cultures … in vitro 3D cell culture to spheroid models, which have very little …
synthetic hydrogel cultures … in vitro 3D cell culture to spheroid models, which have very little …