5-HT2A and 5-HT2C receptors as potential targets for the treatment of nicotine use and dependence

GA Higgins, EM Sellers - Progress in Brain Research, 2021 - Elsevier
therapeutic use of this class should they reach approval status. Additional avenues include
5-HT2C receptor agonists, … dependence, and may have therapeutic potential. It is anticipated …

Molecular and structural insights into the 5‐HT2C receptor as a therapeutic target for substance use disorders

M Ubhayarathna, CJ Langmead… - British Journal of …, 2023 - Wiley Online Library
… Converging studies provide a demonstration of the therapeutic potential of 5-HT2C receptor
… future therapeutic potential for 5-HT2C receptor agonists in SUD, but further scrutiny of …

Contemporary Perspective on 5-HT2C Receptor Function and Its Pharmacological Targeting

P De Deurwaerdère, A Chagraoui… - Frontiers in …, 2020 - frontiersin.org
… prospects 5-HT 2C R ligands as potential therapeutics given its value as a … diseases including
eating disorders, drug addiction, schizophrenia, mood disorders, impulse control disorders

The 5‐HT2C receptor as a therapeutic target for alcohol and methamphetamine use disorders: A pilot study in treatment‐seeking individuals

EJ Campbell, Y Bonomo, A Pastor… - Pharmacology …, 2021 - Wiley Online Library
… strategies for these disorders are ineffective at a population level. Lorcaserin, a 5-HT 2C
receptor agonist, has shown potential at reducing the symptoms of substance use disorder. This …

5-HT receptors 2A and as 5-HT potential

GA Higginsa, EM Sellersb - … and Therapeutic Relevance Part A, 2021 - books.google.com
… of 5-HT receptors, including 5-HT2A and 5-HT2C receptors, … receptor subtypes responsible
for their therapeutic potential, … proposed that 5-HT2C receptor agonists may have potential to …

Improved 5-HT2 selective receptor modulators for the treatment of psychological disorders

RB Kargbo - ACS Medicinal Chemistry Letters, 2021 - ACS Publications
therapeutic potential. The present Patent Highlight showcases compounds with selective
5-HT2C … activity that were devoid of 5-TH2B agonist functional activity. In addition, selected …

[PDF][PDF] Strategies to Identify Therapeutic Opportunities in the Treatment of Addictive Disorders

AE Price - 2020 - utmb-ir.tdl.org
… to a similar therapeutic approach, they are limited by what aspects of an addictive disorder
we can … Serotonin 5HT2C receptor activation suppresses binge intake and the reinforcing and …

Lorcaserin: A review of its preclinical and clinical pharmacology and therapeutic potential

GA Higgins, PJ Fletcher, WR Shanahan - Pharmacology & Therapeutics, 2020 - Elsevier
… may have therapeutic potential for a variety of disorders and conditions beyond … potential
therapeutic indications beyond obesity. Lorcaserin is the first selective 5-HT2C receptor agonist

The Therapeutic Potential of Serotonin 1B Receptor Agonists for Treating Psychostimulant Use Disorders

R Garcia - 2020 - search.proquest.com
… This dissertation aimed to investigation the therapeutic potential of 5-HT1BR ligands to
treat psychostimulant abuse. I investigated if the 5-HT1BR agonist effects observed previously …

Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction

J Jastrzębska, M Frankowska, I Smaga… - Pharmacological …, 2023 - Springer
… Hence, 5-HT 2C receptor agonists, by eliminating animals’ … administration of 5-HT 2C
receptor agonists—RO and WAY—… of 5-HT 2C receptor agonists during extinction training on the …