… ) cells, which secrete the pro-inflammatory cytokine IL-17 (14), but it may … IL-23/IL-17 biology,
and of the many cell types involved, may lead to the identification of new therapeutic targets…

… Interleukin-17 (IL-17) is one of the well-studied cytokines as an important player in the … of
the mechanism of IL-23-Th17 cell, IL-17, which has allowed for more targeted treatments and …

… shown to exacerbate chronic immune-mediated inflammation. Well-… production of the cytokines
(TNF-α, IL-17, IL-6, IL-23) involved in … of new potential therapeutic targets of inflammatory …

… of the cytokines of this pathway; in fact, therapeutics that specifically target IL-23, IL-17, and
IL-… in other immune-mediated diseases such as Crohn's disease, spondylarthritis, and coeliac …

… IL-17, the signature cytokine, have led to important insights into chronic inflammation.
Interleukin-23 (IL-23), a heterodimeric cytokine … of pro-inflammatory cytokines including IL-17, IL-22…

… inflammatory immune-mediated skin disease that … of IL-23 and IL-17 in the pathogenesis of
psoriasis has led to the development of many new biologic therapies targeting these cytokines…

… Abstract: Psoriasis is an immune-mediated skin disease that … , we review the IL-23/Th-17
axis based therapeutic targets, … and IL-23, the different isoforms of IL-17, the IL-17 receptor …

… Most cytokines of the IL-23/IL-17 family act locally rather than systemically. Therefore, it can
be … the IL-23/IL-17 pathway as a key driver of immune-mediated kidney diseases. A direct …

… of both IL-17 and IL-22 arms. This made IL-23 a key target of autoimmune disorders therapy,
which … Immune-mediated disorders are conditions characterized by an uncontrolled immune …

… We discuss the therapeutic rationale for targeting these cytokines to treat … of therapies
targeting IL-23 in AS and axSpA suggests the possibility of a partial uncoupling of IL-23 and IL-17 …