… of cytokines for stimulating immune responses in patients with cancer. However, direct
application of cytokines … cells that mediate the antitumor response and can be precisely targeted. …

… analysis of the current therapies targeting the TME, combining a discussion of the underlying
basic biology with clinical evaluation of different therapeutic approaches, and highlighting …

… Enriched pathways of the molecular targets included cytokine–cytokine receptor interaction,
TNF signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling …

… therapy are regulated by inflammation, which either promotes or suppresses tumor progression,
potentially displaying opposing effects on therapeutic … We also highlight potential targets …

… inhibiting STAT-mediated signalling pathways of numerous cytokines. Thus, mechanism-based
therapies targeting several cytokines and their signalling have brought a paradigm shift …

… However, the therapeutic benefit of these strategies on … , co-stimulation and cytokine production
in the immune synapse … Finally, we highlight the new therapeutic targets emerging from …

… in organization of local immune response in targeted tissues through antigen presentation
of endogenous or exogenous autoantigens, cytokine and chemokine production promoting B …

… our current understanding of the three principal constituents of PDAC stroma, their effect on
the prevalent immune landscape and promising therapeutic targets within this compartment. …

… the therapeutic … therapeutic approaches to target FoxP3 + Tregs expressing other Treg-related
markers such as CD25, C–C chemokine receptor 4 (CCR4), suppressive cytokines and …

… For example, anti-inflammatory cytokines can be used as drugs to treat inflammation-related
diseases. However, cytokine therapy also suffers from a number of limitations as compared …