Structural patterns in class 1 major histocompatibility complex-restricted nonamer peptide binding to T-cell receptors.

T RR, JC Smith - Proteins, 2022 - europepmc.org
… A number of three-dimensional (3D) structures are now available of … molecular-level insights
we analyze structures of TCRs bound to human class I nonamer peptide-MHC complexes. …

[HTML][HTML] Three-dimensional culture models to study innate anti-tumor immune response: advantages and disadvantages

A Poggi, F Villa, JLC Fernadez, D Costa, MR Zocchi… - Cancers, 2021 - mdpi.com
… The anti-PDX effects of human immune cells, in these humanized mice, only partially
resemble the development of a tumor in humans, as tumor microenvironment is complex and …

Fibroblasts/three-dimensional scaffolds complexes promote wound healing in rats with skin defects

T Jiang, Q Liu, EC Xu, SY He, HY Liu, C Tian… - Tissue …, 2024 - Taylor & Francis
… We aim to construct a three-dimensional nano-skin scaffold material in vitro and study its …
of three-dimensional (3D) scaffolds were successfully fabricated by combination of type I

[HTML][HTML] PANDORA v2. 0: Benchmarking peptide-MHC II models and software improvements

FM Parizi, DF Marzella, G Ramakrishnan… - Frontiers in …, 2023 - frontiersin.org
… presented by the Major Histocompatibility Complex (MHC). Investigations into the three-dimensional
(3D) structures of peptide:MHC (pMHC) complexes have provided valuable insights …

[HTML][HTML] Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models

S Bhattacharya, K Calar, P de la Puente - Journal of Experimental & …, 2020 - Springer
… [25], and altered ECM composition [26]. The utilization of three-dimensional (3D) in vitro
models for deciphering the complex tumor immune communications yields dependable …

[HTML][HTML] Three-dimensional vascular microenvironment landscape in human glioblastoma

…, E Saavedra-López, L Romarate, I Mitxitorena… - Acta neuropathologica …, 2021 - Springer
… visualization revealing the cellular composition of human GBM in detail … Our images show
a complex vascular map of human 3D biopsies with … Major histocompatibility complex class II

[HTML][HTML] … Cross-presentation of Donor Major Histocompatibility Derived Epitopes by Recipient Major Histocompatibility Class I Molecules in Transplantation Rejection

S Koothradan, KK Elyas - Indian Journal of Transplantation, 2023 - journals.lww.com
… peptide-MHC class I complex, and class I MHC molecules are … peptide-MHC class II complex,
and class II MHC molecules are … , the three-dimensional (3D) structures of the MHC class I

[HTML][HTML] Sequence-structure-function relationships in class I MHC: A local frustration perspective

O Serçinoğlu, P Ozbek - PloS one, 2020 - journals.plos.org
Class I Major Histocompatibility Complex (MHC) binds short … the most polymorphic protein
in humans. This allelic diversity … does not affect the three-dimensional structure of the complex. …

[HTML][HTML] Generation of complex bone marrow organoids from human induced pluripotent stem cells

S Frenz-Wiessner, SD Fairley, M Buser, I Goek… - Nature …, 2024 - nature.com
… for generating complex BM-like organoids (BMOs) from humanthree-dimensional structures
mimicking cellular, structural … of major histocompatibility complex class II molecules (Fig. 5c). …

[HTML][HTML] The three-dimensional in vitro cell culture models in the study of oral cancer immune microenvironment

E Dalir Abdolahinia, X Han - Cancers, 2023 - mdpi.com
molecules such as MHC class I chain-related protein A and B (MICA and MICB) and the
histocompatibility … is its capability to create complex tissue and organ structures by using diverse …