… that arrange snRNA genes and regulate snRNA … in snRNA expression, the association of
CBs with U2 snRNA genes is dependent on transcription of this gene [Citation16], U2 snRNA …

… Altogether, several of the initially identified snRNAs—including U1, U2, U4, U5, and U6—…
These results indicated that transcription of snRNAs is critical for Cajal body organization on …

… Lastly, the mature U4, U5 and U6 snRNPs organize themselves into a U4-U6 di-snRNP and
U4-U5-U6 tri-snRNP to become fully functional for pre-mRNA splicing (Novotny et al., 2011; …

… contains a variety of nuclear bodies that harbor various RNA-… part in escorting the U4/U6
U5 snRNPs to the spliceosomal … observed the expected high colocalization between the oligo-…

… , the snRNPs mature in aggregates within the nucleus, the so-called Cajal bodies (CBs), …
Immunofluorescence analyses showed colocalization of Gemin2 and p70S6K in the cytoplasm (…

… bodies are often involved in molecular biogenesis, such as the nucleolus in forming
ribosomes and Cajal bodies in processing snRNAs… of the U5, U6, and U4/U6•U5 small nuclear …

… snRNPs are formed by a single U-rich small nuclear RNA (U1, U2, U4, U5, U11 or U12-snRNA…
in CBs, we performed a detailed colocalization analysis from the confocal fluorescent …

… bright Cajal body foci. In the absence of Nopp140, the Mushroom … Nopp140 colocalizes with
snoRNPs in the CB, supporting … of snRNAs into individual snRNP complexes (U1, U2, etc.) …

… The CB is a transcription-dependent nuclear organelle whose … As expected, both TMG-cap
and fibrillarin signals colocalized … correlates with reduced U4/U6-U5 tri-snRNP assembly, a …

… Dephosphorylated serine- and arginine-rich protein SRSF10 (SRP38) binds to U1 snRNP-associated
protein U1 70K, and prevents the interaction of U1 70K with other SR proteins [96]. …