NRF2, a transcription factor for stress response and beyond
F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
… antioxidant response elements (ARE) for activation of gene … bound NRF2 are transcriptionally
regulated by NRF2 binding [… ARE sites for transcriptional repression of NRF2 target NAD(…
regulated by NRF2 binding [… ARE sites for transcriptional repression of NRF2 target NAD(…
[HTML][HTML] Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
S Liu, J Pi, Q Zhang - Redox biology, 2022 - Elsevier
… response elements (ARE) in the promoters of a battery of target genes including … While p62
activates NRF2 through repressing KEAP1, p62 itself is also a transcriptional target of NRF2, …
activates NRF2 through repressing KEAP1, p62 itself is also a transcriptional target of NRF2, …
[HTML][HTML] Anti-ferroptotic effects of Nrf2: beyond the antioxidant response
… regulator of IRP1/2 that binds to the iron responsive element in the 5’-UTR of FTH1 and FTL
mRNA thereby repressing … synthesis) was identified as a novel Nrf2 target gene. Second, …
mRNA thereby repressing … synthesis) was identified as a novel Nrf2 target gene. Second, …
[HTML][HTML] Beyond repression of Nrf2: An update on Keap1
… nor verified in context of Nrf2, were D-… -responsive element-binding protein-regulated
transcription coactivator 1 (CRTC1), myeloid cell leukaemia sequence 1 (MCL1), and splicing factor…
transcription coactivator 1 (CRTC1), myeloid cell leukaemia sequence 1 (MCL1), and splicing factor…
[HTML][HTML] Rare and common genetic variations in the Keap1/Nrf2 antioxidant response pathway impact thyroglobulin gene expression and circulating levels …
… Nrf2 (antioxidant response elements, AREs) were identified in the regulatory region of the TG
gene… diabetes, induction of Nrf2 pathway by sulforaphane can repress gluconeogenesis [7]…
gene… diabetes, induction of Nrf2 pathway by sulforaphane can repress gluconeogenesis [7]…
The NRF2-dependent transcriptional regulation of antioxidant defense pathways: Relevance for cell type-specific vulnerability to neurodegeneration and therapeutic …
SM Boas, KL Joyce, RM Cowell - Antioxidants, 2021 - mdpi.com
… associated with the repression of promoter activity and that the NRF2 expression associated
… gene. Role of AP1 binding site contained within human antioxidant response element. J. …
… gene. Role of AP1 binding site contained within human antioxidant response element. J. …
Involvement of Nrf2 and Keap1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent peptides from soft-shelled turtle
N Wang, W Wang, FA Sadiq, S Wang, L Caiqin… - Process …, 2020 - Elsevier
… The antioxidant response element (ARE) is a cis-acting enhancer sequence … antioxidant
and detoxification. Under oxidative stress, the induction of nuclear factor-E2-related factor 2 (Nrf2…
and detoxification. Under oxidative stress, the induction of nuclear factor-E2-related factor 2 (Nrf2…
Oxidative stress responsive transcription factors in cellular signalling transduction mechanisms
LCP Dharshini, S Vishnupriya, KM Sakthivel… - Cellular …, 2020 - Elsevier
… that can either activate or repress transcription in response to … Studies reveal that a
promising transcriptional regulatory … and adheres to the antioxidant response element (ARE) in …
promising transcriptional regulatory … and adheres to the antioxidant response element (ARE) in …
NF-κB and Keap1 interaction represses Nrf2-mediated antioxidant response in rabbit hemorrhagic disease virus infection
B Hu, H Wei, Y Song, M Chen, Z Fan, R Qiu… - Journal of …, 2020 - Am Soc Microbiol
… suppressor of Nrf2 in the Nrf2-antioxidant response element (… protein between Nrf2 and
Cul3, which sequesters Nrf2 in the … of Nrf2-mediated repression of antioxidant responses in …
Cul3, which sequesters Nrf2 in the … of Nrf2-mediated repression of antioxidant responses in …
The antioxidant transcription factor Nrf2 in cardiac ischemia–reperfusion injury
A Mata, S Cadenas - International journal of molecular sciences, 2021 - mdpi.com
… of genes involved in antioxidant response and drug detoxification. In … underlying the
transcriptional regulation of Nrf2. We also … mediates the repression of Nrf2 transcriptional activity …
transcriptional regulation of Nrf2. We also … mediates the repression of Nrf2 transcriptional activity …