[PDF][PDF] Transcriptome signature of cell viability predicts drug response and drug interaction in Mycobacterium tuberculosis
V Srinivas, RA Ruiz, M Pan, SRC Immanuel… - Cell Reports …, 2021 - cell.com
… of efficacious drug treatment. Using an inferred transcriptome of a drug combination from
single-drug … tool for the prioritization of new multicomponent drug regimens. While we validated …
single-drug … tool for the prioritization of new multicomponent drug regimens. While we validated …
Transcriptome signature of cell viability predicts drug response and drug interaction for Tuberculosis
V Srinivas, RA Ruiz, M Pan, SR Christinal Immanuel… - bioRxiv, 2021 - biorxiv.org
… efficacious drug treatment. Using an inferred transcriptome of a drug combination from
single-drug … Future work also aims to integrate DRonA with regulatory-metabolic networks 30–33 …
single-drug … Future work also aims to integrate DRonA with regulatory-metabolic networks 30–33 …
Uncovering expression signatures of synergistic drug responses via ensembles of explainable machine-learning models
… essential to understand how the efficacy of both Shapley value-… STAT6 (ranked 31st) is a
transcriptional regulator known to … the transcriptomic factors underlying anticancer drug synergy…
transcriptional regulator known to … the transcriptomic factors underlying anticancer drug synergy…
A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs
JM Cicchese, A Sambarey, D Kirschner… - Scientific Reports, 2021 - nature.com
… in designing combination … our predictions of regimen efficacy compare to clinical results,
we compare our INDIGO-MTB—GranSim treatment simulations to results from TB drug clinical …
we compare our INDIGO-MTB—GranSim treatment simulations to results from TB drug clinical …
Integrating pharmacogenomics data-driven computational drug prediction with single-cell RNAseq to demonstrate the efficacy of a NAMPT inhibitor against …
S Mazumder, T Mitra Ghosh, UK Mukherjee… - Cancers, 2022 - mdpi.com
… -genome transcriptomics data between clinically sensitive … regulation were significant among
the IPA-predicted signaling … -agent and DTX combination treatment using Flow cytometry. …
the IPA-predicted signaling … -agent and DTX combination treatment using Flow cytometry. …
Hepatocytic transcriptional signatures predict comparative drug interaction potential of rifamycin antibiotics
… Then, transcriptomic data obtained in NGS is used in a … DDIs and prediction of effectiveness
of a drug regimen during co-… signatures of rifamycin drugs and pathways that regulate …
of a drug regimen during co-… signatures of rifamycin drugs and pathways that regulate …
Pre-clinical tools for predicting drug efficacy in treatment of tuberculosis
H Margaryan, DD Evangelopoulos, L Muraro Wildner… - Microorganisms, 2022 - mdpi.com
… transcriptomic signatures to predict the drivers of drug synergy and clinical regimen efficacy
… of the transcriptional regulatory network (TRN) showed that drug synergy and antagonism …
… of the transcriptional regulatory network (TRN) showed that drug synergy and antagonism …
Personalized tumor combination therapy optimization using the single-cell transcriptome
… and clinical usage using the single-cell transcriptome, which … parameter r in routine Louvain
clustering automatically, which … searched comboSC drug combination predictions in all drug …
clustering automatically, which … searched comboSC drug combination predictions in all drug …
Predicting heterogeneity in clone-specific therapeutic vulnerabilities using single-cell transcriptomic signatures
… of a drug combination over individual drugs was calculated … Going beyond monotherapy,
the ability to predict drug … can be essential for improving treatment efficacy in the clinic [50, 51]. …
the ability to predict drug … can be essential for improving treatment efficacy in the clinic [50, 51]. …
Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
… MAPK cascade and increased regulators of cellular transport and … for the drug combination
to achieve optimal efficiency. It will … cell heterogeneity through a transcriptomic study, it would …
to achieve optimal efficiency. It will … cell heterogeneity through a transcriptomic study, it would …