[PDF][PDF] Transcriptome signature of cell viability predicts drug response and drug interaction in Mycobacterium tuberculosis

V Srinivas, RA Ruiz, M Pan, SRC Immanuel… - Cell Reports …, 2021 - cell.com
… of efficacious drug treatment. Using an inferred transcriptome of a drug combination from
single-drug … tool for the prioritization of new multicomponent drug regimens. While we validated …

Transcriptome signature of cell viability predicts drug response and drug interaction for Tuberculosis

V Srinivas, RA Ruiz, M Pan, SR Christinal Immanuel… - bioRxiv, 2021 - biorxiv.org
efficacious drug treatment. Using an inferred transcriptome of a drug combination from
single-drug … Future work also aims to integrate DRonA with regulatory-metabolic networks 30–33 …

Uncovering expression signatures of synergistic drug responses via ensembles of explainable machine-learning models

JD Janizek, AB Dincer, S Celik, H Chen… - Nature Biomedical …, 2023 - nature.com
… essential to understand how the efficacy of both Shapley value-… STAT6 (ranked 31st) is a
transcriptional regulator known to … the transcriptomic factors underlying anticancer drug synergy

A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs

JM Cicchese, A Sambarey, D Kirschner… - Scientific Reports, 2021 - nature.com
… in designing combination … our predictions of regimen efficacy compare to clinical results,
we compare our INDIGO-MTB—GranSim treatment simulations to results from TB drug clinical

Integrating pharmacogenomics data-driven computational drug prediction with single-cell RNAseq to demonstrate the efficacy of a NAMPT inhibitor against …

S Mazumder, T Mitra Ghosh, UK Mukherjee… - Cancers, 2022 - mdpi.com
… -genome transcriptomics data between clinically sensitive … regulation were significant among
the IPA-predicted signaling … -agent and DTX combination treatment using Flow cytometry. …

Hepatocytic transcriptional signatures predict comparative drug interaction potential of rifamycin antibiotics

SR Dyavar, TM Mykris, LC Winchester, KK Scarsi… - Scientific reports, 2020 - nature.com
… Then, transcriptomic data obtained in NGS is used in a … DDIs and prediction of effectiveness
of a drug regimen during co-… signatures of rifamycin drugs and pathways that regulate

Pre-clinical tools for predicting drug efficacy in treatment of tuberculosis

H Margaryan, DD Evangelopoulos, L Muraro Wildner… - Microorganisms, 2022 - mdpi.com
transcriptomic signatures to predict the drivers of drug synergy and clinical regimen efficacy
… of the transcriptional regulatory network (TRN) showed that drug synergy and antagonism …

Personalized tumor combination therapy optimization using the single-cell transcriptome

C Tang, S Fu, X Jin, W Li, F Xing, B Duan, X Cheng… - Genome Medicine, 2023 - Springer
… and clinical usage using the single-cell transcriptome, which … parameter r in routine Louvain
clustering automatically, which … searched comboSC drug combination predictions in all drug

Predicting heterogeneity in clone-specific therapeutic vulnerabilities using single-cell transcriptomic signatures

C Suphavilai, S Chia, A Sharma, L Tu, RP Da Silva… - Genome Medicine, 2021 - Springer
… of a drug combination over individual drugs was calculated … Going beyond monotherapy,
the ability to predict drug … can be essential for improving treatment efficacy in the clinic [50, 51]. …

Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

AF Aissa, AB Islam, MM Ariss, CC Go, AE Rader… - Nature …, 2021 - nature.com
… MAPK cascade and increased regulators of cellular transport and … for the drug combination
to achieve optimal efficiency. It will … cell heterogeneity through a transcriptomic study, it would …