Multiomics analysis reveals cuproptosis-related signature for evaluating prognosis and immunotherapy efficacy in colorectal cancer
R He, H Zhang, H Zhao, X Yin, J Lu, C Gu, J Gao, Q Xu - Cancers, 2023 - mdpi.com
… five-gene panel for predicting individual patient prognosis, drug sensitivity, tumor-immune …
Next, we further assessed genetic and transcriptomic variants in CRs. Regulatory mutations …
Next, we further assessed genetic and transcriptomic variants in CRs. Regulatory mutations …
Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state
… , was achieved by a combination of horizontal and vertical … gene regulation across conditions
in a single transcriptome … signatures efficiently predict sensitivity to our candidate drugs…
in a single transcriptome … signatures efficiently predict sensitivity to our candidate drugs…
Exploiting the stemness and chemoresistance transcriptome of Ewing sarcoma to identify candidate therapeutic targets and drug-repurposing candidates
EA Roundhill, P Pantziarka, DE Liddle, LA Shaw… - Cancers, 2023 - mdpi.com
… In the future, after preclinical validation of efficacy and … Genes that regulate pluripotency,
stemness and the MDR ABC … in combination with high levels of IGF2BP3 also predicts poor …
stemness and the MDR ABC … in combination with high levels of IGF2BP3 also predicts poor …
A flux-based machine learning model to simulate the impact of pathogen metabolic heterogeneity on drug interactions
CH Chung, S Chandrasekaran - PNAS nexus, 2022 - academic.oup.com
… (determined using chemogenomic or transcriptomic data as input)… Here, we extended our
approach to predict treatment efficacy … gene regulation in response to each drug treatment was …
approach to predict treatment efficacy … gene regulation in response to each drug treatment was …
Exploration of molecular markers related to chemotherapy efficacy of hepatoid adenocarcinoma of the stomach
J Wei, K Ji, Y Zhang, J Zhang, X Wu, X Ji, K Zhou… - Cellular Oncology, 2024 - Springer
… chemotherapy on genome and transcriptome of HAS can help us … predicting drug efficacy
and potential therapeutic targets. … Histone deacetylase inhibitors, an epigenetic regulatory drug…
and potential therapeutic targets. … Histone deacetylase inhibitors, an epigenetic regulatory drug…
Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts
… We investigated the transcriptomic signatures of the R and … to be involved in the regulation
of endothelial cell migration … models are more likely to drive clinical efficacy in man 9 . Our …
of endothelial cell migration … models are more likely to drive clinical efficacy in man 9 . Our …
Identification of a gene panel predictive of triple-negative breast cancer response to neoadjuvant chemotherapy employing transcriptomic and functional validation
R Vishnubalaji, H Abdel-Razeq, S Gehani… - International Journal of …, 2022 - mdpi.com
… regulation (Figure 6b and Table S5). Given the apparent role of immune signatures in
predicting … of RD-associated genes to enhance the efficacy of standard NAC. Our data identified …
predicting … of RD-associated genes to enhance the efficacy of standard NAC. Our data identified …
The clinical relevance and prediction efficacy from therapy of tumor microenvironment related signature score in colorectal cancer
X Jun, S Gao, L Yu, G Wang - Frontiers in Oncology, 2023 - frontiersin.org
… To analyze the transcriptome and immunology heterogeneity of … In combination with the
characterization of the immune … cells, while fibroblasts and regulatory T cells promote the …
characterization of the immune … cells, while fibroblasts and regulatory T cells promote the …
Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology
… of PANoptosis for the prediction of cancer patient survival … To this end, we first compared
the differential regulation of the … Furthermore, the efficiency of the three different survival …
the differential regulation of the … Furthermore, the efficiency of the three different survival …
Single-cell proteomics and tumor RNAseq identify novel pathways associated with clofazimine sensitivity in PI-and IMiD-resistant myeloma, and putative stem-like …
… Next, using genome-wide transcriptome analysis (RNA-… -enabled regulation of cell
adhesion-mediated drug resistance (1–5). … We propose clinical efficacy studies in …
adhesion-mediated drug resistance (1–5). … We propose clinical efficacy studies in …