Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's Disease male mice
… , we are displaying the site without styles and JavaScript. … Adeno-associated viral-(AAV)
NGF gene delivery in a Phase I clinical … and pathological analyses of 3xTg-AD mice. 3xTg-AD …
NGF gene delivery in a Phase I clinical … and pathological analyses of 3xTg-AD mice. 3xTg-AD …
Neurotrophic factors in Alzheimer's disease: Pathogenesis and therapy
… In addition, studies showed that deficits in long‑term … affinity of NGF binding to p75NTR re‑
ceptor is weaker than NGF binding to … nerve growth factor display perinatal loss of sensory and …
ceptor is weaker than NGF binding to … nerve growth factor display perinatal loss of sensory and …
Intranasal transplantation of human neural stem cells ameliorates Alzheimer's disease-like pathology in a mouse model
MH Lu, WL Ji, H Chen, YY Sun, XY Zhao… - Frontiers in Aging …, 2021 - frontiersin.org
… , and pericytic and synaptic loss, while enhancing adult … Our findings show that intranasal
delivery of hNSCs, an … growth factors such as BDNF and NGF and neurotrophin such as NTF3 …
delivery of hNSCs, an … growth factors such as BDNF and NGF and neurotrophin such as NTF3 …
Peptides derived from growth factors to treat Alzheimer's disease
S Gascon, J Jann, C Langlois-Blais, M Plourde… - International Journal of …, 2021 - mdpi.com
… may be linked to pathologies related to depression and … loss of septal cholinergic neurons
with deficits in memory and learning were also observed in heterozygous mutant mice (NGF …
with deficits in memory and learning were also observed in heterozygous mutant mice (NGF …
Differential Regulation of Neurotrophic Factors During Pathogenic Tau-Aggregation in a Tau Transgenic Mouse Model for Alzheimer's Disease: A Protocol for Double …
K Schindowski - Tau Protein: Methods and Protocols, 2024 - Springer
… However, whether it is related to tau pathology is still not clear. … of NGF mRNA was examined
in the tau transgenic mouse model. In non-transgenic controls, distinct cells displaying NGF …
in the tau transgenic mouse model. In non-transgenic controls, distinct cells displaying NGF …
[HTML][HTML] … of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage
S Gonzalez, TLM McHugh, T Yang, W Syriani… - Neurobiology of …, 2022 - Elsevier
… While NGF/TrkA signaling has received the most attention in this … drawing showing a midline
sagittal section of the adult mouse … We previously reported a loss of cholinergic fibers and …
sagittal section of the adult mouse … We previously reported a loss of cholinergic fibers and …
[HTML][HTML] Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer's disease
… Chronic treatment with leptin increased NSCs proliferation with … Collectively, we show that
leptin participates in several … treatment with leptin did not affect the weight loss of animals. …
leptin participates in several … treatment with leptin did not affect the weight loss of animals. …
The nerve growth factor metabolic pathway dysregulation as cause of Alzheimer's cholinergic atrophy
S Do Carmo, B Kannel, AC Cuello - Cells, 2021 - mdpi.com
… NGF metabolic cascade, is described in detail in this review along with its marked dysregulation
in the Alzheimer’s disease (AD) pathology. … strong evidence showing that NGF acts as a …
in the Alzheimer’s disease (AD) pathology. … strong evidence showing that NGF acts as a …
Therapeutic potential of neurotrophic factors in Alzheimer's Disease
A Nasrolahi, F Javaherforooshzadeh… - Molecular biology …, 2022 - Springer
… mice showing AD phenotypes of humans. AEAC can improve neural cell injuries by enhancing
the NGF … of hippocampus-frontal connectivity to AD pathology and AD-related cognitive …
the NGF … of hippocampus-frontal connectivity to AD pathology and AD-related cognitive …
Intranasal delivery of BDNF rescues memory deficits in AD11 mice and reduces brain microgliosis
… memory deficits in AD11 mice, a model of NGF deprivation-induced … in AD11 mice but also
in ameliorating the AD-like pathology, we … However, our data show a decrease in drebrin and …
in ameliorating the AD-like pathology, we … However, our data show a decrease in drebrin and …