Neuropeptidergic control of feeding: Focus on the galanin family of peptides

P Marcos, R Coveñas - International Journal of Molecular Sciences, 2021 - mdpi.com
celastrol protects against obesity by activating the PGC-1α/glucose transporter 4 axis-mediated
glucose consumption, and by suppressing … the treatment of obesity (Figure 5). In addition, …

Celastrol in metabolic diseases: Progress and application prospects

S Xu, Y Feng, W He, W Xu, W Xu, H Yang, X Li - Pharmacological research, 2021 - Elsevier
… , which proves that celastrol protected against obesity by regulating … In addition, celastrol
also showed the ability to suppress … that celastrol has great potential in the treatment of obesity-…

Celastrol: a promising agent fighting against cardiovascular diseases

Z Li, J Zhang, X Duan, G Zhao, M Zhang - Antioxidants, 2022 - mdpi.com
Celastrol was reported to suppress body weight and reduce … in the protection of celastrol
against obesity through both … Another study shows that celastrol protects against palmitate-…

Detection and quantification of the anti-obesity drug celastrol in murine liver and brain

M De Angelis, SC Schriever, E Kyriakou… - Neurochemistry …, 2020 - Elsevier
… of 100 μg celastrol per kg BW, with brain celastrol levels being 4- … understanding on celastrol
as an emerging anti-obesity drug … Prior to the actual analysis of the celastrol-treated mouse …

Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via …

MHA Bakar, KA Shariff, JS Tan, LK Lee - European journal of pharmacology, 2020 - Elsevier
… In this present work, celastrol treatment prevented these adverse effects of HFD on …
Withaferin A protects against high-fat diet–induced obesity via attenuation of oxidative stress, …

Cel-CS1K: A Celastrol–Chitosan Conjugate for Treating Diet-Induced Obesity

H Zeng, Q Tian, C Wang, X Zhu, W Li… - … Research in …, 2024 - ACS Publications
from 2.52% to 2.38% to 3.96% (Figure 2D–F). Hence, the low molecular weight chitosan
oligosaccharide protects against celastrol-… natural product celastrol was found to suppress food …

[HTML][HTML] Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling

L Li, B Wang, Y Li, L Li, Y Dai, G Lv, P Wu, P Li - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
Celastrol has recently been identified as a prospective new treatment for obesity and … of
bone development, which in turn suppressed osteogenic rejuvenation and hematopoiesis [1–4]. …

Celastrol Stabilizes Glycolipid Metabolism in Hepatic Steatosis by Binding and Regulating the Peroxisome Proliferator-Activated Receptor γ Signaling Pathway

M Luo, Y Wang, Y Ma, J Li, J Wang, C Liu - Metabolites, 2024 - mdpi.com
… and obesity to investigate the protective effect of celastrol. We … Furthermore, celastrol
suppressed the impacts on adipocyte … We treated NAFLD cells with celastrol and rosiglitazone in …

Celastrol: an update on its hepatoprotective properties and the linked molecular mechanisms

M Li, F Xie, L Wang, G Zhu, LW Qi… - Frontiers in Pharmacology, 2022 - frontiersin.org
… mechanisms of celastrol in the prevention and treatment of … -1α axis activity and protected
against obesity in HFD mice by … M1 polarization was suppressed by celastrol via regulating …

Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol

Y Lu, Y Liu, J Zhou, D Li, W Gao - Medicinal research reviews, 2021 - Wiley Online Library
… Subsequent studies showed that celastrol reduces inflammation and protects against
Celastrol can facilitate the treatment of obesity by decreasing galanin-induced food intake and …