… Trehalose-6-phosphate phosphatase (TPP) is a key enzyme of the most common trehalose
… attractive target owing to the toxicity of accumulated trehalose-6-phosphate in pathogens. …

… where trehalose synthesis is not induced led to growth inhibition and the accumulation of
trehalose‐6‐phosphate. Our results demonstrate that trehalose‐6‐phosphate affects multiple …

… We report the functional and structural characterization of trehalose-6-phosphate phosphatase
(TPP), from the Gram-negative bacterium B. pseudomallei that causes melioidosis, a …

… such as phosphotransferases caused by sugarphosphatases acting as antimetabolites [38].
The effects of the accumulation of T6P in P. aeruginosa are still unknown. However, the …

… Trehalose 6-phosphate (Tre6P), the intermediate of trehalose biosynthesis, is an essential …
proteins that catalyse its degradation, the trehalose 6-phosphate phosphatases (TPPs). Often …

… Trehalose for various cell survival and transmission purposes [9]. In Cryptococcus
neoformans, trehalose … Overall, one may conclude that trehalose phosphate phosphatases are …

… specificity of trehalose-6-phosphate phosphatases, there are … In previous studies, some
selected generic phosphatase inhibitors … inhibitors for trehalose 6-phosphate phosphatases. …

… [The recently reported structure of a Pseudomonas aeruginosa T6PP homologue is noted;
however, the weak T6P hydrolysis activity reported for this homologue (44) (14 M –1 s –1 …

… in pathogen growth has been reported in Pseudomonas aeruginosa infection of plants.
Here, … For example, trehalose 6 phosphate has been reported to be an inhibitor of the P. …

… Instead, TPS activity in the presence of Mg 2+ with glucose-6-phosphate (G6P) as the
glycosyl acceptor and UDPG or ADPG as the glycosyl donor forming trehalose 6-phosphate was …