… induce H 2 O 2 -mediated cancer cell death, including their … cancer showed that ascorbic
acid-menadione produced an … , such as vitamin K3, triethylenetetramine, or other H 2 O 2 -…

… of such pathological changes and targeted pharmacological therapy [39]. Another target
is protein kinase C (PKC) that is activated by growth factor-mediated phospholipase C (PLC) …

… ascorbic acid mediated direct cytotoxicity effects on cancer cells through hydrogen peroxide
(… Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic …

… Vitamin C (VitC), also known as ascorbic acid or ascorbate, is … species can synthesize ascorbic
acid, humans cannot, and … cancer patients treated with pharmacological doses of VitC (10 …

… , we hypothesized that pharmacological-VC-mediated mTOR … O 2 to water, and/or L-ascorbic
acid 2-phosphate, which is a … with telomerase inhibitors (triethylenetetramine), respiratory …

… of VitC, which forms hydrogen peroxide (H2O2) and reactive … involved in L-ascorbic acid
binding and collagen 623 fibril … 624 activity linked to vesicle-mediated transport (TFRC, AP3S1…

… agent [21] Vitamin C, also known as L-ascorbic acid (AA), is a … (ROS) due to the hydrogen
peroxide formed cause cancer cell … Oxidative stress-mediated signaling events have been …

… The catalytic decomposition of hydrogen peroxide (H 2 O 2 ) … may dictate mitochondria-mediated
apoptosis in cancer cells [74]. … Studies have shown that ROS can mediate apoptosis via …

TP53 (p53) is a pivotal player in tumor suppression with fifty percent of all invasive tumors
displaying mutations in the TP53 gene. In the present study, we characterized colon cancer …

… experimental analog to study the effects of ceramide-mediated processes. C2 concentrations
… important for neural tube closure, since ROS-mediated changes to redox state are not the …