… Further evidence of the trypanocidal action of eupomatenoid-5: confirmation of … trypanocidal
action of eupomatenoid-5 could be associated with mitochondrial dysfunction and oxidative …

… We decided to investigate possible oxidative damage caused by mammea A/BA in the
parasites. … The present study found that the trypanocidal effect of mammea A/BA appears to be a …

… trypanocidal action of eupomatenoid-5 might be associated with mitochondrial dysfunction
and oxidative damage, which can trigger destructive effects on the biological molecules of T. …

… , proposing oxidative stress as a possible trypanocidal mechanism. … action, we reported
variations in the mitochondrial membrane potential, which were directly related to the dysfunction …

… Trypanocidal action of eupomatenoid-5 is related to mitochondrion dysfunction and
oxidative damage in Trypanosoma cruzi. Microbes Infect., (12-13): 1018–24. doi: 10.1016/j.micinf.…

… Eupomatenoid-5, a neolignan extracted from leaves of Piper regnellii var. pallescens, was
shown antileishmanial activity. … and oxidative stress, which leads to mitochondrial dysfunction …

… diseases, especially for neglected disorders. This repositioning approach is … In addition to
induce mitochondrial changes in the … occidentale showed trypanocide effects similar to those of …

… The most frequent effect of chemotherapeutic agents on trypanosomatid mitochondria is
mitochondrial dilation, indicative of a dysfunction in membrane potential. Studies indicate that …

… activity, the DBN obtained from the oxidative coupling of caffeic acid and n-butyl ester displayed
high activity … 1–4 are lower as compared to those of eupomatenoid-5 (IC 50 = 7 µg/mL or …

… the presence of bioactive benzofuran neolignans eupomatenoid-5 (EUP-5)… eupomatenoid-5
(anti-tuberculosis,13,14 antioxidant,15 leishmanicide,16,17 anticarcinogenic,18 trypanocide.…