… solid tumors, pancreatic cancer harbors ample stromal cells … , resulting in persistent and
severe hypoxia within the tumor. … reprogramming, cancer stemness, invasion and metastasis, …

… pancreatic cancer cell invasion and EMT by interfering with tumor‑stromal interaction under
hypoxic … As curcumin can inhibit several important factors secreted by stromal cells, including …

… 6, vascular endothelial growth factor A, and stromal cell-derived … hypoxia-induced pancreatic
cancer cell EMT and invasion. … interaction between pancreatic cancer cells and PSCs under …

… tumor-stromal and tumor-immune cell interactions in the … number of pre-invasive pancreatic
intraepithelial neoplasm (PanIN… and is overexpressed in hypoxic environments, including that …

… discuss the role of hypoxia on metastasis (invasion and migration), stroma and extracellular
… Moreover, only a small portion of tumor cells have cancer stem cell (CSCs) features with the …

… hypoxia. These changes promote EMT that endow the tumor cells with enhanced invasiveness
… CAFs interact with both the tumor cells and immune cells especially M2 TAMs through …

… the interaction among pancreatic cancer cells, epithelial cells … Pancreatic cancer is a hypoxic
tumor with a distinct hypoxic … and enhances invasiveness and the spread of epithelial cells […

… Furthermore, HIF1α stabilization was sufficient to induce an iCAF phenotype in stromal
cells introduced into PDAC organoid cocultures and to promote PDAC tumor growth. These …

… reduced cancer invasiveness and attenuated tumor growth [… , the pancreatic neoplasias
were shown to be highly hypoxic, … , hypoxia signaling modifies the interactions between cancer …

… pertinent interactions and influence of core stromal elements … stem cell expansion, invasion
and metastasis in multiple in … reduced tumour tissue hypoxia and abrogated the pro-invasive …