Human endogenous retroviruses (HERVs): shaping the innate immune response in cancers

V Alcazer, P Bonaventura, S Depil - Cancers, 2020 - mdpi.com
… expression with the innate immune response in cancer. After a brief … between HERVs and
the innate immune response, before … and clonal expansion of tumor-specific cytotoxic T cells (“…

Roles of human endogenous retroviruses and endogenous virus-like elements in cancer development and innate immunity

H Katoh, T Honda - Biomolecules, 2023 - mdpi.com
… or tumor suppressor genes as RNAs or proteins [25,28]. L1 chimeric transcripts or proteins
can change cellular properties and affect certain … in both naïve and primed stem cells and is …

Antiviral responses in cancer: boosting antitumor immunity through activation of interferon pathway in the tumor microenvironment

GAF Vitiello, WAS Ferreira… - … in Immunology, 2021 - frontiersin.org
… and endogenous retroviruses in cancer may enhance tumortumor tissues, including the
clinical use of innate immune … as interferon stimulated genes (ISGs), after binding to specific

Endogenous retroviruses as modulators of innate immunity

E Russ, S Iordanskiy - Pathogens, 2023 - mdpi.com
… to use a methionine tRNA to prime reverse transcription, not … 5 and the upregulation of
interferon stimulated genes (ISGs). … a synergistic effect and increased tumor cell death, likely due …

Endogenous retrovirus activation as a key mechanism of anti-tumor immune response in radiotherapy

AK Lee, D Pan, X Bao, M Hu, F Li… - Radiation …, 2020 - meridian.allenpress.com
… downstream transcription of interferon-stimulated genes. Additionally… and the dsRNA-sensing
innate immunity pathway could be … All other primers were generated using the NCBI Primer

[PDF][PDF] Endogenous Retroviruses as a Key Modulator of Immune Response to Cancer Therapies

AKK Lee - Pharmacology) Chuan-Yuan Li, Adviser, 2020 - dukespace.lib.duke.edu
interferon-stimulated genes through the MDA5/MAVS innate antiviral … of the cellular innate
immune system (X. Li et al., 2013). … Knockout cells used for this study consisted of 3 individual

The immunological conundrum of endogenous retroelements

G Kassiotis - Annual review of immunology, 2023 - annualreviews.org
… responses elicited by endogenous retroviruses and other … responses, such as transcription
of interferon-stimulated … colon tumor derives from an endogenous retroviral gene product …

Human endogenous retrovirus reactivation: implications for cancer immunotherapy

A Petrizzo, C Ragone, B Cavalluzzo, A Mauriello… - Cancers, 2021 - mdpi.com
… adopted by the innate immune system against microbial … the transcription of several
interferon-stimulated genes (ISGs)… , TLR7 and TLR9 were not able to prime natural killer (NK) cells …

Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development

S Sun, F Frontini, W Qi, A Hariharan, M Ronner… - Cancer Letters, 2021 - Elsevier
… 31 cancer types with most prevalent 38-interferon stimulated … are able to activate innate
immunity via the production of type-… -specific primer “M” and unmethylation-specific primer “U” for …

Human Retrotransposons and the Global Shutdown of Homeostatic Innate Immunity by Oncolytic Parvovirus H-1PV in Pancreatic Cancer

M Neulinger-Muñoz, D Schaack, SP Grekova… - Viruses, 2021 - mdpi.com
… /interferon-stimulated genes (IFN/ISG)-circuit and its major configurator, human endogenous
retroviruses (… by conventional PCR using published primer sequences and visualizing PCR …