… Tumor necrosis factor (TNF) and its receptors are widely expressed in non-small cell lung
cancer (NSCLC… resistance to targeted treatment and immunotherapy with checkpoint inhibitors. …

… Therapeutic drugs act as antagonists by blocking the … Several TNF-α inhibitors have been
approved for clinical use: … TNF-α inhibitors utilized as therapeutic drugs against autoimmune …

… Clinically, in patients with rheumatoid arthritis and NAFLD, treatment with TNF inhibitors
also has beneficial effects on hepatic tissue 51 . However, in patients with multiple immune-…

… the efficacy and safety of etrolizumab in patients with moderately to severely active ulcerative
colitis who had been previously treated with anti-tumour necrosis factor (TNF) agents. …

… Tumour necrosis factor (TNF) inhibitors are used in the treatment of certain autoimmune …
Importantly, targeting inflammation using the biological therapy has previously been successful. …

… into the TME with a focus on the effects of tumor necrosis factor-α (TNF-α) on its … cancer
types often acquire treatment resistance to various RTK inhibitors such as VEGFR inhibitors …

… that TNF inhibitor monotherapy was associated with a lower risk of adverse COVID-19
outcomes compared with other commonly prescribed immunomodulatory treatment regimens …

… inhibitors [40, 41]. Based on these findings, several clinical trials have been conducted to test
the therapeutic potential of TNF-α in different types of cancer, … its biological effects in cancer …

… is found in the use of immune checkpoint inhibitor therapeutics. These … tumour cytotoxicity,
through release of mediators such as tumour necrosis factor (TNF), transforming growth factor-…

… Considering the pivotal role of NK cells in cancer biology, they naturally emerged as … cancer
therapy, and a growing number of studies and multiple therapeutic agents inhibiting cancer …