Hypoxia activated HGF expression in pancreatic stellate cells confers resistance of pancreatic cancer cells to EGFR inhibition
… induced the expression and secretion of HGF in PSC via transcription … of pancreatic cancer
cells to EGFR inhibitor in a KRAS-independent manner by activating the PI3K-AKT pathway. …
cells to EGFR inhibitor in a KRAS-independent manner by activating the PI3K-AKT pathway. …
Targeting HGF/c-MET axis in pancreatic cancer
… is the hepatocyte growth factor (HGF)/c-MET pathway. HGF … the invasiveness of a pancreatic
cancer cell line (PK8) that … from fibroblast cell line (MRC5) under hypoxic conditions; …
cancer cell line (PK8) that … from fibroblast cell line (MRC5) under hypoxic conditions; …
HGF/MET Axis induces tumor secretion of tenascin-C and promotes stromal rewiring in pancreatic cancer
C Modica, M Olivero, F Zuppini, M Milan, C Basilico… - Cancers, 2021 - mdpi.com
… receptor by its ligand, the hepatocyte growth factor (HGF), … pair sustains the interaction
between cancer cells and the … acts as a pro-invasive factor on pancreatic cancer cells, little is …
between cancer cells and the … acts as a pro-invasive factor on pancreatic cancer cells, little is …
Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro
J Xu, S Liu, X Yang, S Cao, Y Zhou - Life Sciences, 2020 - Elsevier
… (PC) by secreting hepatocyte growth factor (HGF). The … modulate proliferation, invasion
and migration of cancer cells [24,25]… hypoxia, which becomes a self-perpetuating hypoxia-fibrosis …
and migration of cancer cells [24,25]… hypoxia, which becomes a self-perpetuating hypoxia-fibrosis …
Crosstalk between tumor and stromal cells in pancreatic ductal adenocarcinoma
N Sperb, M Tsesmelis, T Wirth - International journal of molecular …, 2020 - mdpi.com
… into myofibroblasts through the accumulation of the hypoxia-… and invasiveness of primary
pancreatic cancer stem cells. In … -1, and hepatocyte growth factor (HGF), which increase the …
pancreatic cancer stem cells. In … -1, and hepatocyte growth factor (HGF), which increase the …
Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor‑stromal crosstalk under hypoxic conditions via the IL‑6/ERK/NF‑κB axis
W Li, L Sun, J Lei, Z Wu, Q Ma… - Oncology …, 2020 - spandidos-publications.com
… affect pancreatic cancer cell invasion and EMT by interfering with tumor‑stromal interaction
under hypoxic … the hepatocyte growth factor (HGF)/c-Met/survivin pathway, which is negatively …
under hypoxic … the hepatocyte growth factor (HGF)/c-Met/survivin pathway, which is negatively …
Pancreatic stellate cells: Aiding and abetting pancreatic cancer progression
SP Pothula, RC Pirola, JS Wilson, MV Apte - Pancreatology, 2020 - Elsevier
… of organotypic pancreatic tissue cultured under hypoxic … facilitate the invasion and co-migration
of cancer cells through the … PSCs secrete the precursor form of hepatocyte growth factor (…
of cancer cells through the … PSCs secrete the precursor form of hepatocyte growth factor (…
Signaling pathways involved in pancreatic stellate cells activity and interaction with pancreatic cancer cells
NV Stanishevska - Morphologia= Морфологія, 2021 - repo.dma.dp.ua
… hepatoma growth factor gene) under hypoxic conditions under the … invasion through the
hepatocyte growth factor /c-Met/survivin … pathways disrupts tumor-stromal crosstalk and improves …
hepatocyte growth factor /c-Met/survivin … pathways disrupts tumor-stromal crosstalk and improves …
HGF/c-MET inhibition as adjuvant therapy improves outcomes in an orthotopic mouse model of pancreatic cancer
… of hepatocyte growth factor (HGF) and c-MET when used as … of hepatocyte growth factor
(HGF)/c-MET pathway, a major mediator of pancreatic stellate cell (PSC)−PC cell interactions, …
(HGF)/c-MET pathway, a major mediator of pancreatic stellate cell (PSC)−PC cell interactions, …
[HTML][HTML] New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets
… which gives rise to a hypoxic environment. In this state, PC … , hepatocyte growth factor (HGF),
and TNF-α, along with the … This pathway also contributes to cancer invasion by producing …
and TNF-α, along with the … This pathway also contributes to cancer invasion by producing …