… control of protein expression using small molecules, antibodies, and light can offer significant
advantages regarding speed, tunability, and reversibility. … protein expression using degrons …

… finger degron augments affinity for CRBN-pomalidomide (18), we tested degrons extended
… These ON-switch split CARs demonstrated tunable antitumor activity in vitro and in vivo. We …

… and a degron were linked via a HCVcs to a protein of interest … confer tight drug control of
viruses through conditional shutoff … or irreversible readouts, rather than speed or reversibility. …

… partner sensitive to tunable protein degradation upon treatment with a “degrader drug” 7,8,9,…
We next evaluated the reversibility of each technology by performing drug washout …

… We have thus designed a toolkit that allows rapid, inducible, tunable and reversible gene …
Since we identified two potent degron domains (AID and FKBP12 F36V ) and two tunable …

… Degron tags enable rapid and tunable control of target protein levels using small molecules.
The ability to develop tags … Using this approach, the authors evolved a compact zinc-finger …

… a degron domain derived from hepatitis C virus (HCV). The presence of SMASh allows tight
control of the Cas9 stability via a … Cas9 degradation was reversible upon ASV removal that …

… does not affect the production of the tagged protein, while in … the degron degrades the newly
synthesized protein together … Tunable, rapid, and reversible drug control of hCas9 levels …

… , degron systems offer precise, rapid, and reversible post-translational destruction of the target
protein… that incorporates a self-excising degron, (36) leaving no tag in the final expressed …

… Meanwhile, protein knockdown tools that draw inspiration from natural regulatory …
degron-tagged proteins from cells are rapidly emerging. The acute and reversible reduction in …