… Proteolysis tags or degrons were used to modify target proteins for protein-level
regulation … It was verified that the oscillations’ robustness was improved and tunability was …

… through delivery of antibodies that target proteins of interest. Although this approach can be
readily applied to almost any cytosolic protein… Trim-Away protein degradation using IKKα and …

… , OFF-switch control of measles virus RNA replication was shown via small molecule-assisted
shutoff (SMASh)–tags fused C-terminally to the viral P protein 9 . An externally tunable ON …

… loxP scar left from the self-excising cassette method of genome … The Flexon system is tunable
and may be incorporated into … a floxed, degron-tagged gene while simultaneously using a …

… the expression of a synthetic transcription factor at tunable … loop with an RNA-binding protein.
We further demonstrate an … , if the sequestration reaction is reversible and/or it produces …

… While our focus has been on using chemical-genetics to engineer degron tags for
understanding the mechanisms of underlying cancer development, new PROTACs and molecular …

… The expression of this gene is driven by the strong … drives the expression of the other gene
in the antisense plasmid via the … As an experimental control incapable of producing integral …

… copy of a short tag allows protein binding and manipulation. Using Drosophila, we show that
… in vivo in developing organisms and allow protein degradation and protein relocalization. …

… in drug discovery targeting the epigenome, highlighting recent advances the selective
degradation of target proteins using Proteolysis Targeting Chimera (PROTAC) to address drug …

… endogenous proteins to be targeted and their abundance to be precisely altered. This
SMASh technique utilizes proteins fused to a self-removing degron, which allows reversible and …