Type-III interferon stimulated gene TRIM31 mutation in an HBV patient blocks its ability in promoting HBx degradation
F Xu, H Song, Q Xiao, Q Wei, X Pang, Y Gao, G Tan - Virus Research, 2022 - Elsevier
… gene rather than a type I IFN–stimulated gene, and the interaction mode of TRIM5γ–HBx–…
that would work together to inhibit HBV replication by promoting HBx degradation (Fig. 5). In …
that would work together to inhibit HBV replication by promoting HBx degradation (Fig. 5). In …
[HTML][HTML] Role of hepatitis B virus non-structural protein HBx on HBV replication, interferon signaling, and hepatocarcinogenesis
F Wang, H Song, F Xu, J Xu, L Wang, F Yang… - Frontiers in …, 2023 - frontiersin.org
… in promoting HBx degradation and inhibiting HBV replication. … interact with HBx and prevent
HBx-mediated degradation of … , such as TRIM5γ/21/25/26/28/31, degrade HBx viral proteins …
HBx-mediated degradation of … , such as TRIM5γ/21/25/26/28/31, degrade HBx viral proteins …
E3 ubiquitin ligase TRIM21 restricts hepatitis B virus replication by targeting HBx for proteasomal degradation
Y Song, M Li, Y Wang, H Zhang, L Wei, W Xu - Antiviral Research, 2021 - Elsevier
… TRIM21 inhibits HBV gene transcription and replication in HBV … HBx protein is a key regulatory
protein that promotes HBV … that TRIM5γ recruits TRIM31 for HBx degradation to limit HBV …
protein that promotes HBV … that TRIM5γ recruits TRIM31 for HBx degradation to limit HBV …
TRIM25 inhibits HBV replication by promoting HBx degradation and the RIG-I-mediated pgRNA recognition
H Song, Q Xiao, F Xu, Q Wei, F Wang… - Chinese Medical …, 2023 - mednexus.org
… We found that TRIM25 promoted HBx degradation, and … ubiquitination of HBx as well as
promote HBx degradation by the … , TRIM5γ and TRIM31, that worked together to promote HBx …
promote HBx degradation by the … , TRIM5γ and TRIM31, that worked together to promote HBx …
[HTML][HTML] Hepatitis B virus X protein and its host partners
H Song, F Xu, Q Xiao, G Tan - Cellular & Molecular Immunology, 2021 - nature.com
… the HBx protein to inhibit HBV replication … HBx ubiquitination and degradation induced by
two host factors, TRIM31 (K95) 4 and TRIM25 (K90) (unpublished data). Interestingly, TRIM5γ …
two host factors, TRIM31 (K95) 4 and TRIM25 (K90) (unpublished data). Interestingly, TRIM5γ …
[HTML][HTML] Baicalin inhibits the replication of the hepatitis B virus by targeting TRIM25
X Fan, F Wang, H Song, F Xu, X Li, Q Wei, B Lei… - Journal of Traditional …, 2023 - Elsevier
… , 9 while TRIM5γ inhibits HBV replication by promoting the degradation of HBx in association
… Moreover, TRIM14 reduces HBV replication by binding to the C-terminal of the HBx protein …
… Moreover, TRIM14 reduces HBV replication by binding to the C-terminal of the HBx protein …
TRIM56 impairs HBV infection and replication by inhibiting HBV core promoter activity
X Tian, H Dong, X Lai, G Ou, J Cao, J Shi, C Xiang… - Antiviral Research, 2022 - Elsevier
… promotes the expression of IFNs (Tan et al., 2018b). The interaction … TRIM5γ and TRIM31
promotes the ubiquitination of hepatitis BX protein to trigger its degradation and inhibit HBV …
promotes the ubiquitination of hepatitis BX protein to trigger its degradation and inhibit HBV …
[HTML][HTML] STAT3-Dependent Gene TRIM5γ Interacts With HBx Through a Zinc Binding Site on the BBox Domain
H Song, F Xu, X Pang, Q Xiao, Q Wei, B Lei… - Frontiers in …, 2021 - frontiersin.org
… TRIM5γ BBOX and HBx. In … promoting HBx degradation and inhibiting HBV replication. On
the other hand, we noted that the TRIM5γ expression was inhibited by HBV in chronically HBV …
the other hand, we noted that the TRIM5γ expression was inhibited by HBV in chronically HBV …
[HTML][HTML] Interferon and interferon-stimulated genes in HBV treatment
Q Li, B Sun, Y Zhuo, Z Jiang, R Li, C Lin, Y Jin… - Frontiers in …, 2022 - frontiersin.org
… ) as ISG can inhibit HBV gene expression and DNA replication in mouse models (36)… TRIM5γ
and TRIM31 were identified as key genes interacting with HBx that promote its degradation …
and TRIM31 were identified as key genes interacting with HBx that promote its degradation …
[HTML][HTML] Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription
… inhibited HBV core promoter activity [26]; TRIM5γ, TRIM21, and TRIM31 promoted the
ubiquitination of hepatitis BX protein (HBx… does not promote HBV RNA degradation. Collectively, …
ubiquitination of hepatitis BX protein (HBx… does not promote HBV RNA degradation. Collectively, …