… gene rather than a type I IFN–stimulated gene, and the interaction mode of TRIM5γ–HBx–…
that would work together to inhibit HBV replication by promoting HBx degradation (Fig. 5). In …

… in promoting HBx degradation and inhibiting HBV replication. … interact with HBx and prevent
HBx-mediated degradation of … , such as TRIM5γ/21/25/26/28/31, degrade HBx viral proteins …

… TRIM21 inhibits HBV gene transcription and replication in HBV … HBx protein is a key regulatory
protein that promotes HBV … that TRIM5γ recruits TRIM31 for HBx degradation to limit HBV …

… We found that TRIM25 promoted HBx degradation, and … ubiquitination of HBx as well as
promote HBx degradation by the … , TRIM5γ and TRIM31, that worked together to promote HBx …

… the HBx protein to inhibit HBV replication … HBx ubiquitination and degradation induced by
two host factors, TRIM31 (K95) 4 and TRIM25 (K90) (unpublished data). Interestingly, TRIM5γ …

… , 9 while TRIM5γ inhibits HBV replication by promoting the degradation of HBx in association
… Moreover, TRIM14 reduces HBV replication by binding to the C-terminal of the HBx protein …

… promotes the expression of IFNs (Tan et al., 2018b). The interaction … TRIM5γ and TRIM31
promotes the ubiquitination of hepatitis BX protein to trigger its degradation and inhibit HBV …

… TRIM5γ BBOX and HBx. In … promoting HBx degradation and inhibiting HBV replication. On
the other hand, we noted that the TRIM5γ expression was inhibited by HBV in chronically HBV …

… ) as ISG can inhibit HBV gene expression and DNA replication in mouse models (36)… TRIM5γ
and TRIM31 were identified as key genes interacting with HBx that promote its degradation …

… inhibited HBV core promoter activity [26]; TRIM5γ, TRIM21, and TRIM31 promoted the
ubiquitination of hepatitis BX protein (HBx… does not promote HBV RNA degradation. Collectively, …