NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity

N Haider, P Dutt, B van de Kooij, J Ho, L Palomero… - Oncogene, 2020 - nature.com
regulation of p53 transcriptional activity through tyrosine phosphorylation. NEK10 loss increases
cellular proliferation by modulating the p53-… NEK10 and TP53-target gene expression is …

[HTML][HTML] The role of p53 in progression of cutaneous squamous cell carcinoma

M Piipponen, P Riihilä, L Nissinen, VM Kähäri - Cancers, 2021 - mdpi.com
tyrosine kinase (RTK) genes in … p53 to a specific set of gene promoters and in this way
promote oncogenesis [100]. The co-operation of p63 and mutant p53 drives a gene expression

[HTML][HTML] Mitf Involved in Innate Immunity by Activating Tyrosinase-Mediated Melanin Synthesis in Pteria penguin

F Yu, Y Lu, Z Zhong, B Qu, M Wang, X Yu… - Frontiers in …, 2021 - frontiersin.org
… in the mantle, which was responsible for melanin synthesis, nacre formation and innate
immune response, the mantle was then used for gene expression, tyrosinase activity and …

[HTML][HTML] Altered expression of shorter p53 family isoforms can impact melanoma aggressiveness

A Tadijan, F Precazzini, N Hanžić, M Radić, N Gavioli… - Cancers, 2021 - mdpi.com
… To assess the gene expression of TP53, we employed a sophisticated approach in which …
depigmented tumors due to loss of active tyrosinase, which reactivates the EMT signaling …

[HTML][HTML] Mutant p53-associated molecular mechanisms of ROS regulation in cancer cells

M Cordani, G Butera, R Pacchiana, F Masetto… - Biomolecules, 2020 - mdpi.com
P53 is also able to regulate gene expression indirectly by regulating the activity of other …
Recently, we showed that mutant p53 tightly regulates oxidative stress in melanoma cells, …

[HTML][HTML] p53 signaling in cancer progression and therapy

HE Marei, A Althani, N Afifi, A Hasan, T Caceci… - Cancer cell …, 2021 - Springer
… of p53 mutant activities is altered gene expression, and in most … p53 by inhibiting its
expression [97]. As shown in breast [98] and prostate cancer cells [99], wild-type p53 affects tyrosine

[HTML][HTML] Regulation of miRNAs expression by mutant p53 gain of function in cancer

T Madrigal, J Hernández-Monge, LA Herrera… - Frontiers in Cell and …, 2021 - frontiersin.org
p53 mutants. Furthermore, recent studies have revealed how p53 mutants regulate gene
expression … The underlying mechanism may involve the proline-rich tyrosine kinase 2 (Pyk2), …

[HTML][HTML] UP256 inhibits hyperpigmentation by tyrosinase expression/dendrite formation via rho-dependent signaling and by primary cilium formation in melanocytes

MC Kang, JW Lee, TH Lee, L Subedi… - International Journal of …, 2020 - mdpi.com
… The cellular tyrosinase activity and melanin content assay revealed that UP256 decreased
… by regulating the expression of proteins related on melanogenesis including tyrosinase, TRP-…

S-petasin induces apoptosis and inhibits cell migration through activation of p53 pathway signaling in melanoma B16F10 cells and A375 cells

L Guo, JS Kang, NJ Kang, YW Choi - Archives of Biochemistry and …, 2020 - Elsevier
… Then gene expression level of p53 was analyzed using an … The expression level of p53 were
normalized using GAPDH … In this work, s-petasin activated expression of p53 at mRNA and …

[HTML][HTML] Paradoxical role for wild-type p53 in driving therapy resistance in melanoma

MR Webster, ME Fane, GM Alicea, S Basu… - Molecular cell, 2020 - cell.com
… find that wild-type p53 is frequently associated with high Wnt5A expression and show that, …
p53 regulates p21, and we have previously observed that Wnt5A increases p21 expression