Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology

JA Menendez, E Cuyàs, JA Encinar… - Molecular …, 2024 - Wiley Online Library
… In KRAS-mutant pancreatic and lung cancer models, … anti-brain metastasis strategies by
forcing FASN-positive … Therefore, the efficacy of FASNis as anti-metastatic agents may be …

[PDF][PDF] Repurposed Drugs Targeting Cancer Signaling Pathways: Dissecting New Mechanisms of Action Through in Vitro and in Vivo Analyses. Lausanne: Frontiers …

AD Campos-Parra, C Pérez-Plasencia… - 2021 - researchgate.net
… cells to that observed in lung cancer and osteosarcoma. These … mice as well as the anti-brain
metastasis in tail vein injection … functional roles of tyrosine kinases in the progression of ES. …

Current status of lymphangiogenesis: molecular mechanism, immune tolerance, and application prospect

H Deng, J Zhang, F Wu, F Wei, W Han, X Xu, Y Zhang - Cancers, 2023 - mdpi.com
… Ephrin-b2, an Eph receptor tyrosine kinase transmembrane … vessels enhance immunotherapy
efficacy in four ways (… disease, lymphedema, and anti-brain tumor. Biomaterials can …

[HTML][HTML] Recent developments in synthetic approaches for macromolecular prodrugs

J Alex, C Weber, C Guerrero-Sanchez… - Progress in Polymer …, 2024 - Elsevier
… To this end, the general aim in developing nanomedicine is to enhance efficacy, drug … on
the direct chemical surroundings as suggested by the observed half-life time of different alkyl …

Cytoskeletal Remodeling and Gap Junction Translocation Mediates Blood–Brain Barrier Disruption by Non-invasive Low-Voltage Pulsed Electric Fields

NR Rajagopalan, WR Vista, M Fujimori… - Annals of biomedical …, 2024 - Springer
efficacy in preclinical studies with potential applications to diseases affecting the brain [7]. …
In this work, we tested whether head mounted electrodes used for transcranial direct current …

Pharmacology, toxicology, and rational application of cinnabar, realgar, and their formulations

H Guan, Y Xu, C Ma, D Zhao - … ‐Based Complementary and …, 2022 - Wiley Online Library
… , antioxidative stress, and anti-brain-damage effects, and the … via the p38 mitogen-activated
protein kinase-related signaling … amplify the therapeutic efficacy of the other drugs, enabling …

[HTML][HTML] Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy

Y Gong, Z Liu, P Zhou, J Li, YB Miao - Nano TransMed, 2023 - Elsevier
… These metabolites, particularly short-chain fatty acids (SCFAs) and other compounds, have
… and exert direct influence on brain function [3]. Their ability to modulate various physiological …

[PDF][PDF] Design and synthesis of novel narciclasine/pancratistatin analogues as potential anti-brain tumour agents

D Azubuike - 2022 - purehost.bath.ac.uk
… the bulbs of various Amaryllidaceae plants. Narciclasine and pancratistatin both display
powerful … detailed biological evaluation of anti-brain tumour activities and clinical development. …

[HTML][HTML] CD200 immune-checkpoint peptide elicits an anti-glioma response through the DAP10 signaling pathway

E Ampudia-Mesias, F Puerta-Martinez, M Bridges… - …, 2021 - Elsevier
… late-stage melanoma and squamous cell lung cancer. Albeit their efficacy in the clinic, when
used … Direct and indirect IPA interactions with experimental or high confidence scores were …

The phosphatase and tensin homolog gene inserted between NP and P gene of recombinant Newcastle disease virus oncolytic effect test to glioblastoma cell and …

SH Jang, BK Jung, YH An, H Jang - Virology journal, 2022 - Springer
… We did comparison tests PTEN protein expression efficiency … lot of other tumor types such
as breast and lung cancer. Current … until now any kind of direct comparison test between P and …