[HTML][HTML] How do adenosine A2A receptors regulate motor function?

A Mori - Parkinsonism & related disorders, 2020 - Elsevier
… , along with its ultrastructural localization in critical areas/… As a result, many new questions
have arisen requiring … PD suggests that large numbers of adenosine A 2A receptors expressed …

[HTML][HTML] Adenosine A2A receptors control synaptic remodeling in the adult brain

X Xu, RO Beleza, FQ Gonçalves, S Valbuena… - Scientific Reports, 2022 - nature.com
… , we are displaying the site without styles and JavaScript. … abnormally to the outer two-thirds
of granule cell layer 38,40 . … Altogether, these results indicate that the adenosine triggering …

Structure and function of adenosine receptor heteromers

R Franco, A Cordomí, C Llinas del Torrent… - Cellular and Molecular …, 2021 - Springer
… X-ray crystallography or cryogenic electron microscopy (cryo-EM)… at the extracellular orthosteric
binding site triggers local structural … The existence of these interfaces implies two internal …

International union of basic and clinical pharmacology. CXII: adenosine receptors: a further update

AP IJzerman, KA Jacobson, CE Müller… - Pharmacological …, 2022 - ASPET
adenosine receptors, to examine a multitude of receptor structures and novel ligands, to
gauge new pharmacology, and to evaluate clinical trials with adenosine receptorMany clinical …

[HTML][HTML] Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics …

K Prasad, EFJ de Vries, PH Elsinga… - International Journal of …, 2021 - mdpi.com
… These findings suggest the existence of postsynaptic … Using immuno-electron microscopy,
A 2A Rs were mainly … However, when one of the two adenosine binding sites in the A 2A R …

Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives

D Guidolin, M Marcoli, C Tortorella, G Maura… - Progress in Molecular …, 2020 - Elsevier
… of agonists of the two receptors on receptor trafficking, including cell surface expression and
suggesting MV as the carriers of A 2A and D 2 receptors. Transmission electron microscopy

A1 and A2A Receptors Modulate Spontaneous Adenosine but Not Mechanically Stimulated Adenosine in the Caudate

Y Chang, Y Wang, BJ Venton - ACS chemical neuroscience, 2020 - ACS Publications
… of rapid adenosine by adenosine receptors is unclear, and … two main adenosine receptors
in the brain are A 1 receptors, … AMP to adenosine, suggesting spontaneous adenosine is …

[HTML][HTML] Biophysical Dissection of Isolated GPCRs: The Adenosine A2A Receptor under the Bistouries

JL Banères, T Botzanowski, JA Boutin, B Calamini… - Receptors, 2023 - mdpi.com
… ), X-ray diffraction and electron microscopy, among others. All of … isolation of the receptor and
the many biophysical approaches … This study further suggests a scaffolding role for the Gβγ-…

The adenosine A2A receptor in the basal ganglia: Expression, heteromerization, functional selectivity and signalling

R Franco, G Navarro, E Martínez-Pinilla - International Review of …, 2023 - Elsevier
… , many of which are olfactory receptors. This chapter is devoted to the adenosine A 2A receptor
… The current knowledge on the A 2A R indicates that drugs aimed at targeting this receptor

MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP

MW Martynowycz, A Shiriaeva, X Ge… - Proceedings of the …, 2021 - National Acad Sciences
… cryogenic electron microscopy (cryo-EM) have allowed for high-resolution structures of several
… commonly reported wastewater metrics do not indicate when action is needed. Findings …