Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; clinical relevance to peripheral artery disease

JPH Neale, JT Pearson, KN Thomas, H Tsuchimochi… - Scientific reports, 2020 - nature.com
… to the hindlimb microvasculature following prolonged ischemiaghrelin promoted skeletal
muscle regeneration via the modulation of miRNAs-221 & -222 28 , and protected the hindlimb

[HTML][HTML] Effect of unacylated ghrelin on peripheral nerve regeneration

G Ronchi, P Tos, E Angelino, L Muratori… - European Journal of …, 2021 - ncbi.nlm.nih.gov
… Moreover, UnAG promotes skeletal muscle regeneration in … of UnAG in promoting peripheral
nerve regeneration after two … weight, fiber cross-sectional area distribution and hindlimb

[HTML][HTML] Both ghrelin deletion and unacylated ghrelin overexpression preserve muscles in aging mice

E Agosti, M De Feudis, E Angelino, R Belli… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
promoting muscle regeneration or preventing skeletal mass loss in different disease models,
including hindlimb ischemia… of muscle atrophy and limiting skeletal muscle regeneration

Regulation of Skeletal Muscle Lipid Metabolism by Ghrelin

EM Hoecht - 2023 - atrium.lib.uoguelph.ca
Unacylated ghrelin (UnAG) has an emerging role in the … Insulin signalling promotes
glucose uptake into skeletal muscleFollowing hind-limb skeletal muscle collection for GSV …

Acylated ghrelin receptor agonist HM01 decreases lean body and muscle mass, but unacylated ghrelin protects against redox-dependent sarcopenia

R Ranjit, H Van Remmen, B Ahn - Antioxidants, 2022 - mdpi.com
… We tested direct effects of ghrelin in skeletal muscle in vivo without its activation on …
tissues after in vivo treatment. Unacylated ghrelin promoted proliferation and myotube fusion in …

Extracellular vesicles from adipose stem cells prevent muscle damage and inflammation in a mouse model of hind limb ischemia: role of neuregulin-1

F Figliolini, A Ranghino, C Grange… - … and Vascular Biology, 2020 - Am Heart Assoc
… pro-angiogenic and skeletal muscle protective properties that … prevent muscle damage after
acute hindlimb ischemia. … in myoblasts, ASC-EVs promote endothelial cell proliferation and …

Desacyl-ghrelin, not just an inactive form of ghrelin?-A review of current knowledge on the biological actions of desacyl-ghrelin

H Iwakura, T Ensho, Y Ueda - Peptides, 2023 - Elsevier
… -ghrelin is derived from the unacylated remnant ghrelin … plasma ghrelin levels observed
after desacyl-ghrelin … of C2C12 skeletal muscle cells via p38 MAPK pathway [101]. In …

Integrative Review of Ghrelin Family Peptides, Musculoskeletal Health and Osteoporotic Fractures

L Fisher, A Fisher - 2024 - books.google.com
… We briefly describe the cells producing acylated and unacylated ghrelin, obestatin (all three
… the following sub-sections expand upon direct GFP regulation of bone and skeletal muscle (…

Acylated ghrelin as a multi-targeted therapy for Alzheimer's and Parkinson's disease

N Reich, C Hölscher - Frontiers in Neuroscience, 2020 - frontiersin.org
… pathways following GHS-R1α activation by AG or ghrelin … -associated muscular atrophy in
the murine hindlimbs and prevented the … While ghrelin is often praised for its ability to promote

Angiogenesis in diabetic mouse model with critical limb ischemia; cell and gene therapy

SL Asadi-Yousefabad, P Nammian, SMB Tabei… - Microvascular …, 2022 - Elsevier
… population of cells after in vitro expansion using an inverted … transplantation of hADSC
recovered hind limb blood flow and … -126 promoted angiogenesis in the ischemia via the secretion …