CpG oligonucleotides as vaccine adjuvants
N Kayraklioglu, B Horuluoglu, DM Klinman - DNA Vaccines: Methods and …, 2021 - Springer
… of CpG ODN to act as adjuvants in animal models of immune … cellular and humoral immune
responses were diminished [… class CpG ODN was incorporated into a VLP and used as an …
responses were diminished [… class CpG ODN was incorporated into a VLP and used as an …
Self-assembled nanospheres mediate phototherapy and deliver CpG oligodeoxynucleotides to enhance cancer immunotherapy of breast cancer and melanoma
G Yu, F Dong, W Ge, L Sun, L Zhang, L Yuan, N Li… - Nano Today, 2022 - Elsevier
… a persistent immune response. In this study, we used an important immune adjuvant (CpG …
therapy can be used to release TAAs and deliver immunostimulatory CpG ODNs to dendritic …
therapy can be used to release TAAs and deliver immunostimulatory CpG ODNs to dendritic …
CpG oligodeoxynucleotide developed to activate primate immune responses promotes antitumoral effects in combination with a neoantigen-based mRNA cancer …
Q Li, J Ren, W Liu, G Jiang, R Hu - Drug Design, Development and …, 2021 - Taylor & Francis
… synthetic CpGs are superb vaccine adjuvants in both mice and humans. In this study, we
were interested in the identification of an optimal B class CpG for use as an immune activator in …
were interested in the identification of an optimal B class CpG for use as an immune activator in …
CpG immunostimulatory oligodeoxynucleotide 1826 as a novel nasal ODN adjuvant enhanced the protective efficacy of the periodontitis gene vaccine in a …
G Bai, H Yu, X Guan, F Zeng, X Liu, B Chen, J Liu… - BMC Oral Health, 2021 - Springer
… IL-15 as adjuvant provoked protective immunity in the periodontal … evaluated the immune
effect of pVAX1-HA2-fimA plus CpG-… In this study, CpG-ODN 1826 was used as an adjuvant to …
effect of pVAX1-HA2-fimA plus CpG-… In this study, CpG-ODN 1826 was used as an adjuvant to …
CpG adjuvant in allergen-specific immunotherapy: finding the sweet spot for the induction of immune tolerance
G Montamat, C Leonard, A Poli, L Klimek… - Frontiers in …, 2021 - frontiersin.org
… AIT relies on the use of adjuvants and immune modulators to … Among the adjuvants tested
for their clinical efficacy, CpG … of CpG oligodeoxynucleotides (CpG-ODN) on the immune …
for their clinical efficacy, CpG … of CpG oligodeoxynucleotides (CpG-ODN) on the immune …
The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants
Z Liang, H Bao, Z Yao, M Li, C Chen, L Zhang, H Wang… - Biomaterials, 2024 - Elsevier
… used as adjuvants, but with limited cellular immune responses. To overcome this limitation,
CpG oligodeoxynucleotides (ODNs) have been used in … combined usage of Alum and CpG is …
CpG oligodeoxynucleotides (ODNs) have been used in … combined usage of Alum and CpG is …
CpG oligodeoxynucleotides for anticancer monotherapy from preclinical stages to clinical trials
… preference for TLR agonists as adjuvants in clinical trials. … of immune cells, recognizes
not only unmethylated CpG di-… The application of CpG 7909 in blood cancer was examined …
not only unmethylated CpG di-… The application of CpG 7909 in blood cancer was examined …
Non-Modified CpG Oligodeoxynucleotide Forming Guanine-Quadruplex Structure Complexes with ε-Poly-L-Lysine Induce Antibody Production as Vaccine Adjuvants
D Zhao, ATT Tu, M Shobo, NBT Le, C Yoshikawa… - Biomolecules, 2022 - mdpi.com
… uptake of G4-CpG ODNs, we used a positively charged … of G4-CpG ODN on both mouse
and human immune cells [26]. … -PLL was used as a carrier for delivering G4-CpG ODNs. The …
and human immune cells [26]. … -PLL was used as a carrier for delivering G4-CpG ODNs. The …
[HTML][HTML] CpG-containing oligodeoxynucleotides and freund adjuvant in combination with alum augment the production of monoclonal antibodies against recombinant …
MK Kohnehshahri, N Delirezh… - Avicenna Journal of …, 2022 - ncbi.nlm.nih.gov
… HBsAg and alum was used with CpG ODN or Freund adjuvants, and splenocytes of …
therefore, CpG-ODN has gained attention for its potential use as an immune adjuvant and in …
therefore, CpG-ODN has gained attention for its potential use as an immune adjuvant and in …
Development of CpG oligodeoxynucleotide TLR9 agonists in anti-cancer therapy
… role in the innate and adaptive immune responses. To date, … (ODN) have been regarded as
a promising vaccine adjuvant as … MGN1703 has been used in a number of clinical trials as a …
a promising vaccine adjuvant as … MGN1703 has been used in a number of clinical trials as a …