[HTML][HTML] Luteolin relieves lung cancer-induced bone pain by inhibiting NLRP3 inflammasomes and glial activation in the spinal dorsal horn in mice

YS Zhou, Y Cui, JX Zheng, YQ Quan, SX Wu, H Xu… - Phytomedicine, 2022 - Elsevier
… lung cancer-induced bone pain are poorly understood, underscoring the need for an in-depth
understanding of the … Current animal studies have demonstrated that lung cancer-induced

What Did We Learn About Fracture Pain from Animal Models?

A Radulescu, FA White, C Chenu - Journal of Pain Research, 2022 - Taylor & Francis
… fracture pain and develop new therapies for treating fracture pain. … the different animal models
for fracture pain research and … our understanding of fracture pain, both human and animal

[HTML][HTML] The TREK-1 potassium channel is involved in both the analgesic and anti-proliferative effects of riluzole in bone cancer pain

M Delanne-Cuménal, S Lamoine, M Meleine… - Biomedicine & …, 2024 - Elsevier
… effects of riluzole on prostate cancer-induced bone pain. We … We chose a mouse model
of bone pain induced by intratibial … Because of the limited understanding of the mechanisms …

miR-155-5p in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain

Q He, L Liu, Y Wang, C Xu, M Xu, J Fu, J Zhu… - … Pain, 2022 - journals.sagepub.com
… To identify the bone cancer pain animal model’s … modulatory role in the bone cancer-induced
nociceptive response, we … To understand whether miR-155-5p is related to BCP and pain-…

[HTML][HTML] The importance of animal models in biomedical research: current insights and applications

A Domínguez-Oliva, I Hernández-Ávalos… - Animals, 2023 - mdpi.com
… In this regard, recognizing degrees of cancer-induced bone pain has been studied by …
Animal models based on rodent species are being used to improve our understanding of …

[HTML][HTML] Animal models of multiple myeloma bone disease

SH Mehdi, S Nafees, SJ Mehdi, CA Morris… - Frontiers in …, 2021 - frontiersin.org
… three-dimensional (3D) cancer-induced osteolytic lesions in mice and … Current MMBD
therapy is still aimed at pain control and … Therefore, a thorough understanding of each model’s …

Efficacy and Receptor Activity of Mitragynine and Speciogynine in Attenuating Cancer-Induced Bone Pain Associated Mechanical Allodynia

YT Ortiz, S Mukhopadhyay, CR McCurdy… - … Journal of Pain, 2024 - jpain.org
… rodent models, synaptic pain plasticity within this pathway has been characterized previously.
Our goal was to understand … To this end, we used patch-clamp electrophysiology to target …

Spinal Nrf2 translocation may inhibit neuronal NF‐κB activation and alleviate allodynia in a rat model of bone cancer pain

J Fu, C Ni, HD Ni, LS Xu, QL He, H Pan… - Journal of …, 2021 - Wiley Online Library
animal experiments were performed between 8:00 and 20:00. During the operation, a heating
blanket was used … As shown in Figure 5a, SFN inhibited bone cancerinduced mechanical …

[HTML][HTML] Neuropathic pain feature in cancer-induced bone pain: does it matter? a prospective observational study

N Zinboonyahgoon, C Luansritisakul - The Korean Journal of Pain, 2023 - ncbi.nlm.nih.gov
… cells is thought to be a major component of metastatic bone pain [4], current evidence also
… in the pathophysiology of cancer-induced bone pain (CIBP). In animal models, it was shown …

Blocking Cancer–Nerve Crosstalk for Treatment of Metastatic Bone Cancer Pain

X Chu, H Zhuang, Y Liu, J Li, Y Wang… - Advanced …, 2022 - Wiley Online Library
… [ 3 ] Quite evidently, a precise understanding of how this reciprocal system operates will …
Moreover, the released AZ-23 after LDH degradation fundamentally inhibited cancer-induced