Pediatric antibiotic stewardship: optimization of vancomycin therapy based on individual pharmacokinetics

K Kreitmeyr, A Pecar, R Mikolajczyk… - The Pediatric …, 2021 - journals.lww.com
vancomycin dosing, TDM timing, as well as targeted troughimprovement of vancomycin
therapy and, therefore, patient safety. … or loading doses for vancomycin were not used routinely. …

Vancomycin therapeutic drug monitoring in paediatrics

J Patel, CJ Lucas, J Ryan, M Jenkins… - … Paediatrics and Child …, 2020 - Wiley Online Library
… The pharmacokinetics (PK) and pharmacodynamics of … Nephrotoxicity is often defined as an
increase in serum … examine whether the current dosing and TDM of paediatric patients in the …

Vancomycin therapeutic drug monitoring in children: new recommendations, similar challenges

JC McNeil, SL Kaplan - The Journal of Pediatric …, 2020 - meridian.allenpress.com
vancomycin pharmacokinetics in children with regards to … vancomycin dosing and
pharmacokinetics in children, 50% … in which a child is improving on therapy without achieving the …

A moving target—vancomycin therapeutic monitoring

AN Burns, JL Goldman - Journal of the Pediatric Infectious …, 2020 - academic.oup.com
… inter- and intra-individual pharmacokinetic (PK) variability, therapeutic drug monitoring (TDM…
pediatric data failed to demonstrate improved clinical outcomes with vancomycin trough

The benefit of individualized vancomycin dosing via pharmacokinetic tools: a systematic review and meta-analysis

N He, S Su, Y Yan, W Liu… - Annals of …, 2020 - journals.sagepub.com
… -guided individualized dosing could significantly increase the … , the specific method used
for vancomycin dosing in each … Determining the optimal vancomycin daily dose for pediatrics

Optimizing vancomycin dosing in pediatrics: a machine learning approach to predict trough concentrations in children under four years of age

M Yin, Y Jiang, Y Yuan, C Li, Q Gao, H Lu… - International Journal of …, 2024 - Springer
… and vital signs that could improve dosing accuracy [22]. PPK … such as pediatric patients,
whose vancomycin pharmacokinetics and … The test set was used to predict vancomycin trough

Comparing Vancomycin Area Under the Curve With a Pharmacist Protocol that Incorporates Trough and Maximum Doses at a Children's Hospital

BO Al-Mazraawy, JE Girotto - The Journal of Pediatric …, 2021 - meridian.allenpress.com
… was performed evaluating vancomycin usage from October … To assess potential kidney
injury, individual patients' serum … an initial vancomycin dose of ≥ 70 mg/kg/day to increase the …

Continuous infusion vancomycin in pediatric patients: a critical review of the evidence

HL Girand - The Journal of Pediatric Pharmacology and …, 2020 - meridian.allenpress.com
… and must have evaluated vancomycin use in children (birth … leads to improved clinical
outcomes in critically ill children. … affect vancomycin pharmacokinetics and subsequent dosing

Population pharmacokinetic models of vancomycin in paediatric patients: a systematic review

E Chung, J Sen, P Patel, W Seto - Clinical Pharmacokinetics, 2021 - Springer
Vancomycin is commonly used to treat gram-positive bacterial … in the paediatric population,
but dosing can be challenging. Population pharmacokinetic (popPK) modelling can improve

Optimization of Pediatric Antibiotic Dosing Through Therapeutic Drug Monitoring

F Zhu - Current Treatment Options in Pediatrics, 2022 - Springer
… Excellent review of the increasing use of pediatric population … Improved vancomycin dosing
in children using area under the … Population pharmacokinetics and dosing optimization of …