Contractile adaptation of the left ventricle post-myocardial infarction: predictions by rodent-specific computational modeling

EA Mendiola, S Neelakantan, Q Xiang… - Annals of biomedical …, 2023 - Springer
… Accordingly, the strains have been used as metrics to evaluate myocardial revascularization
efficiency and predict patient outcomes with heart failure. Previous studies have found both …

Heart failure: how to optimize guideline-directed medical therapy

F Crea - European Heart Journal, 2022 - academic.oup.com
… This Focus Issue on heart failure (HF) and cardiomyopathies … ‘Left ventricular remodelling
post-myocardial infarction: … use alternative drug interventions such as sacubitril/valsartan

Sex differences in heart failure medications targeting the renin-angiotensin-aldosterone system

PA Nicolaou - European Journal of Pharmacology, 2021 - Elsevier
… clinical usefulness in the treatment of hypertension and are not currently used in the … valsartan
and valsartan groups, respectively. The interaction between sex and the effect of treatment

[HTML][HTML] QGC606: A best-in-class orally active centrally acting aminopeptidase A inhibitor prodrug for treating heart failure following myocardial infarction

SE Boitard, M Keck, R Deloux, PE Girault-Sotias… - Canadian Journal of …, 2022 - Elsevier
post-myocardial infarction (MI) in mice was determined 1 hour after oral QGC606 (25 mg/kg)
or firibastat (150 mg/kg) treatment … disulfide bridge, 10 we used a similar strategy to increase …

[PDF][PDF] An Update on Myocardial Infarction

SN Fathima - Current Research and Trends in Medical Science …, 2021 - researchgate.net
… life-threatening arrhythmias and congestive heart failure as … as well as heart failure, is
frequently accompanied by signs of … These are used mainly as an alternative in patients who can’…

Potential utility of SPECT/CT with 99mTc-Tektrotyd for imaging of post-myocardial infarction inflammation

SI Sazonova, JN Ilyushenkova, AG Syrkina… - Journal of Nuclear …, 2023 - Elsevier
patients with ST-segment elevation myocardial infarction (STEMI) develop adverse LV
remodeling and post-infarct heart failure… possible directions for the use of myocardial scintigraphy …

[HTML][HTML] Angiotensin receptor-neprilysin inhibition (ARNI) in heart failure

B Greenberg - International Journal of Heart Failure, 2020 - ncbi.nlm.nih.gov
… Sacubitril-valsartan should not be used in patients with a history of angioedema in … of
post-myocardial infarction (MI) ventricular remodeling in which treatment with sacubitril-valsartan

SGLT2 Inhibitors Squeak Out a Win in Patients Post-MI

JA Udell - NEJM evidence, 2024 - evidence.nejm.org
… , in patients with acute myocardial infarction (MI) without type 2 diabetes (T2D) or heart failure
(… death or hospitalization for HF (10.9% sacubitril/valsartan vs. 11.8% ramipril) was twofold …

Effect of Angiotensin Receptor Blocker Dose in Myocardial Infarction With Preserved Left Ventricular Systolic Function

HY Kim, J Mok, JY Kim, D Jeon, SH Her… - … of Cardiovascular …, 2023 - journals.lww.com
… For the this study, target doses for the most commonly used ARB were as follows: valsartan
320 mg/d… Are hospitalized or ambulatory patients with heart failure treated in accordance with …

Network model‐based screen for FDA‐approved drugs affecting cardiac fibrosis

AC Zeigler, AS Chandrabhatla… - CPT …, 2021 - Wiley Online Library
… and day 42 of post-myocardial infarction simulation The combination drug valsartan/sacubitril
(… used to improve cardiac function in patients with heart failure. The model predicts that the …