… key risk factors to understand the pathogenesis of the disease and to develop more effective
… associated with puberty may be involved in osteosarcoma etiology. In elderly patients, …

… However, improvements in our understanding of the biology … current knowledge of disease
pathophysiology, highlighting … the genomic and immune landscapes of osteosarcoma have …

… Recent interest in understanding the pathophysiology and genetics of osteosarcoma
resulted in several genomic studies using whole-genome sequencing (WGS) and/or whole-exome …

… of MSCs using COBRA-FISH karyotyping and CGH array revealed the occurrence of
aneuploidization, translocations, and homozygous loss of CDKN2 region of the genome these cells, …

… and adolescents, has a poorly understood genetic etiology. … with studies of osteosarcoma
tumor genomes where recurrent … progress in understanding the genetic epidemiology of many …

… , and current diagnostic and treatment strategies. The disease … research to enhance
understanding of the disease, refine … Genome Atlas (TCGA) provides comprehensive genomic …

… the mechanisms of genome instability in OS would thus aid in our understanding of … therapy
+ immunotherapy combinations in the treatment of osteosarcoma is the lack of single agent …

… difficult to study from an epidemiologic perspective. Our understanding of risk factors for
the … The descriptive epidemiology of osteosarcoma strongly suggests an etiology related to …

… , 19 -21 affirming a complex underlying architecture for its genetic etiology but one that …
associated with osteosarcoma that were identified through the Human Genome Epidemiology (…

… our understanding of different molecular aberrations that occur with respect to the genomic
… At present, two cellular events are postulated to play a role in osteosarcoma pathogenesis. …