The VEGF/VEGFR axis revisited: implications for cancer therapy

P Mabeta, V Steenkamp - International journal of molecular sciences, 2022 - mdpi.com
growth factor receptor (VEGFR) axis is indispensable in the … an improvement in both overall
survival and progression-free … other VEGF family members, namely, VEGF-B and PlGF [18,20]…

The role of the VEGF family in coronary heart disease

Y Zhou, X Zhu, H Cui, J Shi, G Yuan, S Shi… - Frontiers in …, 2021 - frontiersin.org
… and ischemia by growing novel blood vessels. Lymphangiogenesis can … VEGF-B bears
a weak angiogenesis capacity, but still plays a significant role in vascular growth and survival

Vascular endothelial growth factor-D (VEGF-D): An angiogenesis bypass in malignant tumors

SMZ Bokhari, P Hamar - International Journal of Molecular Sciences, 2023 - mdpi.com
… involved in cell growth, proliferation, and survival, as well … VEGF-B has two isoforms which
can bind and activate VEGFR-1. It mainly maintains new blood vessels and prevents vascular

Exploring the intracrine functions of VEGF-A

S Wiszniak, Q Schwarz - Biomolecules, 2021 - mdpi.com
… While a clear biological role for VEGF-B is yet to be defined, … axon guidance independent of
its roles in blood vessels [12,13]. … examples kinase activity was dispensable [27,28]. It will be …

Susceptibility to cardiac arrhythmias and sympathetic nerve growth in VEGF-B overexpressing myocardium

J Lähteenvuo, OP Hätinen, A Kuivanen, J Huusko… - Molecular Therapy, 2020 - cell.com
… Nerve and blood vessel development and growth occur in … Vascular endothelial growth
factors (VEGFs) regulate blood … to regulate neuron growth, differentiation, and survival, thus …

VEGF-B is an autocrine gliotrophic factor for müller cells under pathologic conditions

M Llorián-Salvador, P Barabas… - … & visual science, 2020 - iovs.arvojournals.org
… that the VEGF-B pathway is not essential for Müller cell survival under … Our results suggest
that autocrine VEGF-B is important for Müller cells to maintain the expression of important

Therapeutic potential of VEGF-B in coronary heart disease and heart failure: dream or vision?

R Mallick, S Ylä-Herttuala - Cells, 2022 - mdpi.com
… patients by stimulating blood vessel growth, improving tissue … is dispensable for the VEGF-B
induced microvascular growth in … to sustain activated endothelial cell survival. Furthermore, …

Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models

C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
… and growth of new blood vessels from pre-existing vessels … [5,6], is instead dispensable
for normal development and … high VEGF-B expression showed poorer survival compared to …

[PDF][PDF] Vascular endothelial growth factor B interferes with angiogenesis and the electrical functions of the heart: pre-clinical studies of intramyocardial gene therapy

OP Hätinen - 2020 - erepo.uef.fi
… We hypothesized that VEGF-B would induce angiogenesis via … With respect to the
formation of a new blood vessel, the … Nrp-2 is not indispensable for embryonic development of …

Expansion and collapse of VEGF diversity in major clades of the animal kingdom

K Rauniyar, H Bokharaie, M Jeltsch - Angiogenesis, 2023 - Springer
… importance for the development of blood vessels as it was the … melanogaster PVFs in immune
function [35], survival of glia … ) were thought to lack PlGF and VEGF-B, but we could find, in …