… pestis infection mainly requires CD4 + and/or CD8 + T cells, … In our previous study, oral
vaccination with the live attenuated Y. … Previous findings have shown the synergistic role of Th1- …

… LcrV antigens of Yersinia pestis was evaluated for its vaccine potential in a … pestis-specific
memory T cells eliciting TNF-α and IFN-γ rather than only … All the experiments handling live Y. …

… pSMV13 for high synthesis of the Yersinia pestis LcrV antigen. The … pestis infection (28), we
determined whether lung T cell … are required to synergistically defend against pulmonary Y. …

… ability of vaccine-induced antibodies to protect macrophages … cells from Yersinia enterocolitica
convalescent mice partially … T cells often produce IL-22 which acts synergistically with IL-…

… still listed the live attenuated Y. pestis vaccine as one of new-generation plague vaccines
[15]… pestis [25] and also thwarted T cell defense against the plague [29]. Removal of Pla clearly …

… T cell cytokine level after immunization with EV76-B-SHU or EV76-… On day 21 after the first
immunization, T cells were isolated … that T cell-mediated immunity, including CD4 + and CD8 + …

… groups at 14 and 28 dpi, and an increase in T cell cytokine responses to both Y. … CD4+ or
CD8+ T cells alone, suggesting that both T cell types work synergistically to protect against Y. …

… -cell, live-attenuated, and recombinant subunit vaccines. … transfer of T cells from immune
mice can protect naive mice … pestis infection by needle injection elicits a potent neutrophil …

… antigens other than F1 and LcrV can also be recognized by T cells [65]. Enhancing the
cellular immunity elicited by live-attenuated vaccines towards these antigens other than F1 and …

… role of T cells in vaccine-mediated immunity, if these cells are not … mutation in the pigmentation
locus of Yersinia pestis PRR … Vaccination with live yersinia pestis primes CD4 and CD8 T …