Letermovir vs valganciclovir for prophylaxis of cytomegalovirus in high-risk kidney transplant recipients: a randomized clinical trial

AP Limaye, K Budde, A Humar, F Vincenti… - Jama, 2023 - jamanetwork.com
valganciclovir developed CMV disease through week 28. Time to onset of … the valganciclovir
group had breakthrough viremia while receiving prophylaxis and 2 developed CMV disease

Impact of valganciclovir prophylaxis duration on cytomegalovirus disease in highrisk donor seropositive/recipient seronegative heart transplant recipients

H Imlay, AO Dumitriu Carcoana… - … Infectious Disease, 2020 - Wiley Online Library
… To assess antiviral prophylaxis duration and other risk factors for CMV disease, … valganciclovir
prophylaxis duration among groups of patients who did and did not develop CMV disease. …

The association between cytomegalovirus infection and cardiac allograft vasculopathy in the era of antiviral valganciclovir prophylaxis

D Klimczak-Tomaniak, S Roest, JJ Brugts… - …, 2020 - journals.lww.com
higher risk of CAV in patients with CMV breakthrough infection among patients on VGCV
prophylaxisCMV infection and development of CAV in HTx patients. The only exception is the …

The burden of cytomegalovirus infection remains high in highrisk kidney transplant recipients despite six‐month valganciclovir prophylaxis

J Räihä, F Ortiz, L Mannonen, R Loginov… - … Infectious Disease, 2021 - Wiley Online Library
… However, 8 patients developed CMV infection within 6 months after … valganciclovir prophylaxis
in CMV high-risk patients. Also, the systematic monitoring for CMV DNAemia in patients

Efficacy and safety according to the dose of valganciclovir for cytomegalovirus prophylaxis in transplantation: network meta-analysis using recent data

JH Lee, H Lee, SW Lee, SD Hwang, JH Song - Transplantation …, 2021 - Elsevier
… the low-dose and high-dose groups were more likely to develop leukopenia (low-… highest
risk of CMV infection, and when the recipient's immunity decreases by administration of a high-…

… valganciclovir treatment in cytomegalovirus highrisk abdominal solid organ transplant recipients may promote development of cytomegalovirus‐specific cell mediated …

MR Jorgenson, H Kleiboeker, N Garg… - … Infectious Disease, 2022 - Wiley Online Library
… with severe or persistent CMV infection, patients developed CMV-specific CMI after … These
data suggest that using letermovir in place of valganciclovir for secondary prophylaxis may …

Comparison of standard versus low‐dose valganciclovir regimens for cytomegalovirus prophylaxis in highrisk liver transplant recipients

AL Bixby, L Fitzgerald, JM Park, D Kaul… - … Infectious Disease, 2021 - Wiley Online Library
… , none of the 16 patients that developed CMV disease were … Therefore, it was possible that
the higher risk of CMV disease … -fold increase in the risk of CMV disease with the use of VGCV …

… to prevent cytomegalovirus after kidney transplantation using prophylaxis in serological highrisk patients and a pre‐emptive strategy in intermediate‐risk patients …

R Hellemans, V Wijtvliet, K Bergs… - … Infectious Disease, 2021 - Wiley Online Library
… Pre-emptive treatment or treatment of CMV disease consisted of high-dose valganciclovir
receiving 6 vs 3 months of VGC prophylaxis developed CMV disease in 16% vs 37% in the first …

Detection of ganciclovir-resistant cytomegalovirus in a prospective cohort of kidney transplant recipients receiving subtherapeutic valganciclovir prophylaxis

DD Wong, WJ van Zuylen, T Novos… - Microbiology …, 2022 - Am Soc Microbiol
developed CMV infection after discontinuing prophylaxis; 4/6 of these recipients developed
CMV disease … of AUC 24 to identify those patients at greater risk, for whom earlier testing for …

A randomized trial of valganciclovir prophylaxis versus preemptive therapy in kidney transplant recipients

T Reischig, T Vlas, M Kacer… - Journal of the …, 2023 - journals.lww.com
… response associated with an increased risk of T-cell–… and prevent the development of
CMV disease in the late post… preemptive valganciclovir therapy, and (4) CMV disease with …