A Retrospective Case Series on Valproic Acid for Early Post-Traumatic Seizure Prophylaxis After Traumatic Brain Injury in Patients With Concomitant Agitation

D Nicole Gilliam, P Sarangarm… - Hospital …, 2023 - journals.sagepub.com
prophylaxis and agitation is limited. The purpose of this study is to examine the safety
and efficacy of valproic acid for both early post-traumatic seizure prophylaxis and agitation. …

[HTML][HTML] Effectiveness of antiseizure medications therapy in preventing seizures in brain injury patients: A network meta-analysis

X Huo, X Xu, M Li, L Xiao, Y Wang, W Li… - Frontiers in …, 2022 - frontiersin.org
… The interventions involved the use of ASMs such as phenytoin, valproate, PB, LAM, LEV, …
The total NOS score of the included 18 non-randomized trials was above 5, indicating high …

[HTML][HTML] … efficacy of prophylactic anticonvulsant drugs following traumatic brain injury: A systematic review and network meta-analysis of randomized controlled trials

BC Wang, HY Chiu, HT Luh, CJ Lin, SH Hsieh… - PloS one, 2022 - journals.plos.org
study by using version 2 of the Cochrane tool for assessing risk of bias in randomized trials
(… phenytoin and other AEDs, including levetiracetam and valproate, were compared [9]. The …

[HTML][HTML] Effect of levetiracetam and valproate on late-onset post-traumatic seizures

Y Wang, Y Wang, H Wang, X Du, J Miao, JX Tao… - Acta Epileptologica, 2023 - Springer
… of late post-traumatic seizures in the LEV group was significantly lower than those in the
valproate … The cumulative incidence of late post-traumatic seizure in the valproate group was not …

[HTML][HTML] Multicenter and prospective trial of anti-epileptics for early seizure prevention in mild traumatic brain injury with a positive computed tomography scan

M Pease, M Zaher, AJ Lopez, S Yu… - Surgical Neurology …, 2022 - ncbi.nlm.nih.gov
Posttraumatic seizures (PTSs) are a major source of disability after … seizures before
arrival at the hospital were prescribed AEDs for therapeutic intent and excluded from this study

[HTML][HTML] Discontinuation of Levetiracetam and Valproic Acid Due to Adverse Effects in Early Post-traumatic Seizure Prophylaxis

SM Pathak, R Ziechmann, J Menzer, A Hoeft… - Cureus, 2023 - ncbi.nlm.nih.gov
… Introduction: Levetiracetam (LEV) and valproic acid (VPA) are two anti-epileptic drugs (AEDs)
routinely used for post-traumatic seizure (PTS) prophylaxis at our institution. In our practice…

[HTML][HTML] Preventing epilepsy after traumatic brain injury: a propensity score analysis

JH Liou, YL Chang, HT Lee, MF Wu… - Journal of the …, 2020 - journals.lww.com
… In a randomized study, TBI patients were administered phenytoin (… on late PTE, treatment
with PHE decreased the early seizure rate … , valproic acid, and levetiracetam with the non-AED …

Comparison of the efficacy and safety of sodium valproate versus levetiracetam in the treatment of severe traumatic brain injury

X Huang, W Lin, J Wang, C Liu, G Wei… - International Journal …, 2024 - Taylor & Francis
… stress, thereby indirectly contributing to the prevention of seizures and post-traumatic epilepsy.
By integrating these preventive measures into the treatment regimen, our goal was to not …

Use of Anti-epileptic Drugs for Post Traumatic Seizure: A Global Survey

H Gopalan, KP - Annals of neurosciences, 2023 - journals.sagepub.com
… In our survey 91.8% of people were giving AED for seizure prophylaxis in TBI, while …
treatment although prophylactic use of phenytoin or valproate is not recommended for preventing

Early seizure prophylaxis in mild and moderate traumatic brain injury: a systematic review and meta-analysis

M Pease, A Mittal, S Merkaj, DO Okonkwo… - JAMA …, 2024 - jamanetwork.com
… absolute risk reduction of seizure prophylaxis for early posttraumatic seizures was 0.6% in
Valproate therapy for prevention of posttraumatic seizures: a randomized trial. J Neurosurg. …