Sacubitril/valsartan mitigates cardiac remodeling, systolic dysfunction, and preserves mitochondrial quality in a rat model of mitral regurgitation
L Tantisuwat, N Saengklub, P Boonpala… - Scientific Reports, 2023 - nature.com
… on cardiac function, mitochondrial quality, autophagy, mitophagy, … In addition, SAC/VAL
significantly reduced myocardial … upregulation is responsible for dysfunctional protein turnover …
significantly reduced myocardial … upregulation is responsible for dysfunctional protein turnover …
[HTML][HTML] Sacubitril/valsartan combination enhanced cardiac glycophagy and prevented the progression of murine diabetic cardiomyopathy
DSA Elshenawy, NM Ramadan, VB Abdo… - Biomedicine & …, 2022 - Elsevier
… myocardium were markedly relieved by sacubitril/valsartan … /valsartan-treated diabetic group
showing autophagic vacuoles (… sufficient for the basal turnover of cardiomyocyte glycogen …
showing autophagic vacuoles (… sufficient for the basal turnover of cardiomyocyte glycogen …
Mitophagy in hypertension-associated premature vascular aging
ZJ Schreckenberger, CF Wenceslau… - … of Hypertension, 2020 - academic.oup.com
… Currently, our understanding of how autophagy exerts a … damaged mitochondria followed
by recruitment of autophagic … are numerous clinical and experimental drugs that have shown …
by recruitment of autophagic … are numerous clinical and experimental drugs that have shown …
[HTML][HTML] Fenofibrate reduces cardiac remodeling by mitochondrial dynamics preservation in a renovascular model of cardiac hypertrophy
L Castiglioni, P Gelosa, M Muluhie, B Mercuriali… - European Journal of …, 2024 - Elsevier
… on mitochondria in a rat model of renovascular hypertension, … of mitochondrial dynamics
and mitophagy/autophagy, to … dynamic in which the physiological mitochondrial turnover is …
and mitophagy/autophagy, to … dynamic in which the physiological mitochondrial turnover is …
Mitophagy in hypertension-mediated organ damage
Y Ma, X Zhou, M Gui, L Yao, J Li, X Chen… - Frontiers in …, 2024 - frontiersin.org
… Overexpression of DNA-damage regulated autophagy … of obesity and hypertension also
contributes to myocardial fibrosis and … Valsartan can regulate mitophagy-related genes to inhibit …
contributes to myocardial fibrosis and … Valsartan can regulate mitophagy-related genes to inhibit …
MSTN attenuates cardiac hypertrophy through inhibition of excessive cardiac autophagy by blocking AMPK/mTOR and miR-128/PPARγ/NF-κB
H Qi, J Ren, L Ba, C Song, Q Zhang, Y Cao… - … Therapy-Nucleic Acids, 2020 - cell.com
… Mitochondrial turnover in the heart. … with the cardiac autophagy and hypertrophy regulated
by MSTN, we … cardiovascular diseases, such as hypertension and myocardial infarction, and is …
by MSTN, we … cardiovascular diseases, such as hypertension and myocardial infarction, and is …
Mitochondrial effects of common cardiovascular medications: the good, the bad and the mixed
AM Bețiu, L Noveanu, IM Hâncu, A Lascu… - International Journal of …, 2022 - mdpi.com
… hemodynamics by regulating blood pressure and volume … and promoting mitochondrial
fusion and autophagy in aged … 2 diabetes, valsartan increased the mitochondrial respiratory …
fusion and autophagy in aged … 2 diabetes, valsartan increased the mitochondrial respiratory …
[HTML][HTML] Sacubitril/valsartan reduces proteasome activation and cardiomyocyte area in an experimental mouse model of hypertrophy
M Meyer-Jens, K Wenzel, K Grube, J Rüdebusch… - Journal of Molecular and …, 2024 - Elsevier
… -dependent, strictly regulated and highly selective multistep … Autophagy has been identified
as a mediator of HF [28,29]. … ligation (myocardial infarction [MI]), a decreased autophagic flux …
as a mediator of HF [28,29]. … ligation (myocardial infarction [MI]), a decreased autophagic flux …
The role of autophagy in cardiovascular pathology
… and reperfusion injury, myocardial infarction, cardiac hypertrophy, … Autophagy activation
is a tightly regulated process that … indicated that autophagosomes can form at mitochondria-…
is a tightly regulated process that … indicated that autophagosomes can form at mitochondria-…
Current understanding of the pivotal role of mitochondrial dynamics in cardiovascular diseases and senescence
Y Uchikado, Y Ikeda, M Ohishi - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
… mitochondrial biogenesis and mitochondrial turnover. … for mature autophagy, and is
accompanied by autophagic … therapeutic target regarding of hypertension and vascular …
accompanied by autophagic … therapeutic target regarding of hypertension and vascular …