Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

MP Murphy, H Bayir, V Belousov, CJ Chang… - Nature …, 2022 - nature.com
… are affected by continuously varying rates of generation, chemical reaction and diffusion. …
controls: does the response change over time and with the amount of biological sample in a …

[HTML][HTML] Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms …

DM Merino, LM McShane, D Fabrizio… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
… a continuous score: This analysis will characterize the analytical performance of the assay
over the analytical range of interest … Consideration should be given to technical and biological

AI-driven quantification, staging and outcome prediction of COVID-19 pneumonia

G Chassagnon, M Vakalopoulou, E Battistella… - Medical image …, 2021 - Elsevier
… with clinical and biological comorbidities for the quantification and … and hence suffers from
inter- and intra-observer variability. … Lastly, we present possible directions for future research. …

Quantifying behavior to understand the brain

TD Pereira, JW Shaevitz, M Murthy - Nature neuroscience, 2020 - nature.com
quantification and highlight promising future directions, with … of pose as a biologically relevant
representation of behavior—… ) and a continuous axis of variation that transitions smoothly …

Organosulfates in ambient aerosol: state of knowledge and future research directions on formation, abundance, fate, and importance

M Brüggemann, R Xu, A Tilgner… - Environmental …, 2020 - ACS Publications
… transitions but rather show a continuous, reversible uptake and … -to-shot variability, impeded
an accurate quantification of OSs in … Ways for a reliable quantification of NOS should be an …

Measuring biological aging in humans: A quest

L Ferrucci, M Gonzalez‐Freire, E Fabbri… - Aging cell, 2020 - Wiley Online Library
… with aging, but the direction and magnitude of change are different in different circulating
cells … , there is continuous epigenetic tuning of the predefined gene expression in response to …

Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2

H Specht, E Emmott, AA Petelski, RG Huffman… - Genome biology, 2021 - Springer
… on low variability for the relative protein quantification derived … most proteins change gradually
across a continuous spectrum, … A step in this direction is replacing the expensive and time-…

Want to model a species niche? A step-by-step guideline on correlative ecological niche modelling

N Sillero, S Arenas-Castro, U Enriquez‐Urzelai… - Ecological …, 2021 - Elsevier
… best practices for calculating correlative ecological niche … variable response curves, and
a map representing a continuous … in ecology, biogeography, and climate change biology (…

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

DW Belsky, A Caspi, L Arseneault, A Baccarelli… - Elife, 2020 - elifesciences.org
… is sensitive to variation in pace of biological aging among … with change in motor coordination
was consistent in direction, … We analyzed continuous outcome data using linear regression. …

Tutorial: guidelines for the computational analysis of single-cell RNA sequencing data

TS Andrews, VY Kiselev, D McCarthy, M Hemberg - Nature protocols, 2021 - nature.com
… -than-expected variance) 42 . For datasets with thousands of cells quantified using UMIs, it
… to introns, it enables the inference of the direction in which each cell is moving in expression …